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Application of the Chinese version of the addiction profile index (API) in drug users: an analysis of validity and measurement invariance across genders



In China, substance use disorders represent a significant burden on public health and the economy. However, while the range of drugs and drug markets expands and diversifies, the instruments available to evaluate users’ dependence statuses from multiple dimensions have become insufficient. Accordingly, the present study presents the Chinese version of the Addiction Profile Index (API), explores its reliability and validity, and investigates the measurement invariance between males and females with substance use disorders.


The API, a self-report questionnaire, was administered to 2252 people with substance use disorders who were undergoing treatment in compulsory detoxification institutions located in five provinces in China (943 females; mean age = 33.5 years old, SD = 8.6). Additionally, to ensure the authenticity of the collected data, the study’s volunteers completed the Drug Use Disorders Identification Test (DUDIT), DUDIT-Extended (DUDIT-E), and the Health Scale for Drug Abusers (HSDA).


The revised API, with its updated substance list, featured 34 items. The new four-factor model, incorporating behavioral symptoms of dependence, impact on social life, cravings, and motivations for detoxification, explained 55.30% of the total variance, indicating a good fit. Moreover, Cronbach’s α and mean item coefficient values showed good internal consistency reliability. Regarding criterion validity, the revised factors were moderately to highly correlated with their corresponding subscales in the DUDIT, DUDIT-E, and HSDA. In addition, the multigroup confirmatory factor analysis demonstrated that a measurement invariance of the revised four-factor model across genders was supported, fully assuming different degrees of invariance. The three factors of symptoms, social life, and motivation exhibited significant differences between male and female participants in the t test results (p < 0.01).


The Chinese version of the API shows good psychometric properties in terms of reliability and validity, and exhibits measurement equivalence across the genders. Therefore, it could be used to comprehensively assess the severity of drug dependence in people with substance use disorders.


Substance use disorder (SUD), characterized by a cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues to use the substance despite significant substance-related problems [1], is acknowledged to be a worldwide public health problem. By the end of 2018, around 2.40 million drug users were officially registered in China [2]; methamphetamine was the most commonly used drug, with around 56.1% of all registered drug users reporting “ice” (methamphetamine) use, followed by heroin and ketamine, the use of both of which has increased rapidly in recent years and accounts for about 39.6% of drug users. Influenced by globalization, there have been several changes seen in the varieties and structures of drug use in China. Apart from the dominant position of the new synthetic amphetamine-type stimulants (ATS) drugs, the polydrug use issue is becoming more prominent with each passing day. As the China National Narcotic Control Commission reported [3], the mixing of opioids and other drugs with synthetic ATS drugs is taking place with increasing regularity since the synthetic drugs entered the market, in order to enhance their dependence effects.

Responding to the country’s serious and complicated drug situation, the Chinese government has been exerting considerable efforts and implementing targeted strategies in order to try to control it, especially in terms of prevention and harm reduction [3,4,5]. Firstly, laws and regulations have been enacted or modified (e.g., the Anti-Drug Law, the Regulation on Drug Rehabilitation) to explicitly stipulate that people found using drugs will be detained for up to 15 days, and people with substance use dependency will be sent for rehabilitation. In addition, there have been reductions in the opium poppy supply from the “Gold Triangle” area, and the “5–14” drug source interception mechanism has been further improved to stop drugs entering China, especially in Yunnan Province and the Guangxi Zhuang Autonomous Region. Thirdly, a variety of health education activities have been organized for young people, including classes on drug prevention and drug education information disseminated through multiple forms such as television, the internet, community interviews, and newspapers. Regarding harm reduction strategies, outreach activities incorporating voluntary HIV tests and privacy protection, methadone maintenance treatments, and needle-syringe programs have been carried out.

In recent years, three types of treatment settings have become available for drug users in China: compulsory isolated rehabilitation centers, voluntary detoxification institutions, and community-based drug rehabilitation and treatment [6]. Under Chinese law, drug users who have refused to receive community-based rehabilitation, or have failed to maintain abstinence in the community, or have been arrested for suffering from a severe drug use disorder will be sent for two years to a compulsory isolated rehabilitation center managed by the Ministry of Justice. In the voluntary detoxification institutions run by the local departments of health, medical treatments including methadone maintenance treatment are provided for 7 to 30 days. The community-based drug rehabilitation and treatments, organized by local government and sub-district offices, undertake periodical inspections and provide job training and psychological treatment for three years to individuals released from the compulsory detoxification institutions.

However, the instruments currently used in such institutions are not suitable for evaluating the dependence severity of individuals’ drug use disorders. One issue is that the questionnaires’ evaluation of dependence severity is constrained by the drug types featured in the questionnaires. While new patterns of synthetic drug and polydrug use are becoming increasingly prevalent, the existing measurement instruments are mainly aimed at traditional substances (e.g., opioid drugs or alcohol, with the corresponding instruments including the Opioid Addiction Severity Inventory and the Penn Alcohol Craving Scale), and so are not suitable for being generalized to individuals dependent on the new synthetic drugs (e.g., ice, ketamine, etc.) or those who abuse multiple drug types [7,8,9]. Secondly, while some widely used instruments with multiple dimensions (e.g., the Addiction Severity Index) theoretically can be used for a comprehensive assessment, professional feedback from physicians is also needed, which takes so much time to implement that it becomes unworkable in actual clinical practice [10, 11]. Thirdly, due to limited access to or availability of some categories of participants, a number of the scales have been developed through reference to a small sample size or low numbers of female drug users [12], which means that their efficacy or applicability cannot be generalized to the total population as they are not sufficiently representative.

Endeavoring to address this gap, the Chinese version of Addiction Profile Index (API) was introduced and firstly developed with reference to a large sample of drug users, especially a representative proportion of female participants, thereby exhibiting greater representativeness in terms of sampling [13]. Moreover, the self-reporting scale takes a convenient amount of time to complete and has multiple dimensions, with dependence severity assessed comprehensively yet expediently. Lastly, referring to the results of the questionnaire, including an attached drug-use list, detoxification institutions will be better able to formulate the corresponding therapeutic schedules or management programs for drug users, no longer constrained by today’s increasingly diversified substance categories.

Findings from previous studies have indicated a significant difference between genders with respect to the severity of drug dependences, which could be related to differences in physical characteristics or social demands (e.g., social responsibility, social roles, etc.) [14, 15]. Equally, though, it is possible that the discrepancies observed between the genders might be a result of the design of the measurements themselves, rather than corresponding to actual differences between female and male drug users. Therefore, when evaluating dependence severity, it will be necessary to assess the measurement equivalence of the psychological scale across genders.

Overall, the present study examines the psychometric properties of the API in China and explores the measurement invariance across genders to provide more accurate information regarding respective dependence severities.



The participants in the current study were randomly recruited from nearly 33 compulsory detoxification institutions in five provinces in China (i.e., Guangdong, Shanxi, Sichuan, Guizhou, and Hunan). All participants with substance use disorders met the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the International Classification of Diseases (ICD-10). The exclusion criteria were: 1) participants were in the period of acute withdrawal; 2) participants were suffering from major mental disorders, infectious diseases, or some form of physical disability;3) age < 18 years; and 4) participants had a relatively low level of education and could not independently complete the test(≤grade 2 of primary school).

The final sample consisted of 2252 participants, including 58.13% (1309) men and 41.87% (943) women. No financial incentives were given to participants in our study. Even though it meant decreased workloads for those participants for the day—their salaries were paid as usual.

This study was approved by the Medical Ethics Committee of the Second Xiangya Hospital, Central South University (Changsha, China). Participation in this study was entirely voluntary to ensure the authenticity and validity of the collected data. All participants provided written informed consents prior to the initiation of the study.



The API, a self-reported questionnaire, was established by Ogel in 2012 [13] for assessing the severity of drug dependence. The original version consisted of 37 items divided into the following five dimensions: 1) 12 items on the characteristics of substance use (a drug-use list); 2) 8 items on the diagnosis of dependence; 3) 10 items on the effects of substance use on the user; 4) 4 items on craving; and 5) 3 items on motivation to quit using substances. In general, the API was a valid and reliable questionnaire.

Drug use disorders identification test (DUDIT)

This scale was developed by Berman in 2003 [16]. It consists of 11 items for screening individuals with drug problems from the following three aspects: symptoms of dependence, physical and psychological problems related to substance use, and frequency of substance use. The results obtained from individuals with severe dependence and healthy participants showed that the scale had a satisfactory reliability and validity.

DUDIT–extended (DUDIT-E)

The scale Evren et al. [17] developed consists of 41 items separated into four subscales: drug frequency (D), positive (P) negative (N), and treatment (T). The results of the reliability and validity analysis revealed that the scale exhibited good psychometric properties, which could be used for further and more detailed assessment of drug-related problems.

Health scale for Chinese drug abusers (HSDA)

This scale was developed by Cai in 2008 [18], and is used to comprehensively evaluate the physical and mental health of drug users. It consists of 120 items separated into the following 11 factors, the results of the validity and reliability analysis revealed that the scale exhibited satisfactory psychometric properties for the evaluation of people with drug use disorder in China.


With the authorization and approval of Ogel, a Chinese version of the API was developed using the Brislin standard back-translation technique [19]. Besides, a semi-structured interview [5, 20] was used in 24 voluntary participants with drug use disorder to explore the rationality of the items and enhance the suitability of each item for the actual drug use by Chinese users. Meanwhile, the investigators were trained on providing consistent instruction and attitude toward the participants to establish a standardized test. The purpose of the test was explained and the confidential nature of the study was emphasized during the test to improve participant cooperation and reliance.

Subsequently, the nationwide data were formally collected. All participants signed an informed consent form before the test began. After completion of the API, the DUDIT, DUDIT-E, and HSDA were administered to a proportion of users for the assessment of criterion-related validity. The whole process of the test was performed in silence, with suitable tables and chairs supplied, a pen with black ink, and spectacles as necessary. In addition, there were no more than 30 participants in each setting, and all the questionnaires were completed within 40 min.

Data analysis

Double-entry and validation were performed with EpiData 3.1 to establish the database [21]. Confirmatory factor analysis (CFA) was conducted using the statistical software Mplus 7.0, while the SPSS version 21.0 software was used for other data analyses.

It was noted that the participants in the factor analysis were randomly divided into two equal groups: one for exploratory factor analysis (EFA) and another for CFA. Other validity analyses of the questionnaires were conducted in all participants. Data processing chiefly comprised the following steps.

  • Step 1: Item analysis. The scores of the total API were ranked from the lowest to the highest in ascending order. Of the participants, 27% were at the top and the bottom of this ranking (i.e., high-score group and low-score group, respectively). An independent sample t-test was used to examine the difference between the high-score group and the low-score group [22].

  • Step 2: EFA. Principal component factor analysis with orthogonal varimax rotation was used to extract the common factor in the first half of the sample (sample 1), with an eigenvalue of > 1.0 for factor extraction. Besides, items with a factor loading of 0.4 or greater were considered to contribute to the factor. PCA was implemented to all items of API which were treated as a single group and analyzed together, except for a drug-use list.

  • Step 3: Reliability. Cronbach’s alphas (α) and mean inter-item correlations (MIC) were used to evaluate the internal reliability of the API. In general, the Cronbach’s α coefficients above 0.70 is considered acceptable but an α of 0.60 is also used [23]. An optimal range of 0.10–0.50 was set for the MIC; lower than 0.10 and it is unlikely that a single total score could adequately represent the complexity of the items; higher than 0.50 and the items on a scale to be overly redundant and the construct measured too specific [24]. The relationships between the total scale and the five facets were also examined using Pearson’s r.

  • Step 4: Validity. a.) To analyze the construct validity, maximum likelihood estimation in CFA was used to confirm the new factorial structure model in the second split-half of the sample (sample 2). As a chi-square test is susceptible to the sample size, even a small difference would result in a significance as the sample size increases. Accordingly, there were three fit indices in the present study: the root mean square error of approximation (RMSEA), comparative fit index (CFI), and Tucker Lewis index (TLI) [25, 26]. The criteria together used to evaluate model fit were as follows: TLI ≥ 0.90, CFI ≥ 0.90, and RMSEA≤0.08. Meanwhile, the factorial structures of the original version and the Chinese version were compared, and the model that fitted the data better was chosen for the subsequent measurement invariance analysis. b.) Besides, criterion-related validity was assessed using the Pearson correlation coefficient, wherein validity is considered good if the value obtained is between 0.4 and 0.7 [27]. Therefore, the correlation coefficient of the API with its corresponding subscales in the DUDIT, DUDIT-E, and HSDA were calculated.

  • Step 5: Measurement invariance. After identification of the best fitting API model, the measurement invariance across genders in the total sample was examined through multigroup CFA under the framework of the structural equation model from the following four degrees: configural invariance, weak factorial invariance, strong factorial invariance, and strict invariance. Furthermore, CFI and TLI differences were used to evaluate invariance across consecutive models: both ΔCFI ≤0.01 and ΔTLI ≤0.01 were considered evidence of invariance, as suggested by Cheung and Rensvold [28].


Descriptive statistics and item analysis

The demographic information of the 2252 participants randomly recruited from the compulsory detoxification institutions may be summarized as follows: 1) there were 139 males for every 100 females; 2) the mean age was 33.52 years old, with a standard deviation of 8.6; 3) most of the participants were unemployed (about 47.29% of all participants); and 4) the substances mainly used were opioids and amphetamines. Other demographic information is illustrated in Table 1.

Table 1 Demographic data of the drug users in this study

For the item analysis. An independent-sample t-test was utilized to explore the difference between the two groups (27%). The results showed that 25 items exhibited satisfactory discrimination among them.


Principal component analysis with orthogonal varimax rotation was conducted to explore the best fitting factor model of the API in a random split-half of the whole sample (n = 1126). The results exhibited that the Kaiser–Meyer–Olkin was good (0.931) and Bartlett’s test of sphericity was statistically significant (P < 0.01), demonstrating suitability for the EFA [29]. Four factors were obtained on the basis of the normal extraction factor of the eigenvalue > 1.0, accounting for 55.30% of the total variance. As shown in Table 2, the results indicated that all 25-item loadings of the API to corresponding factors were > 0.40 in the current study. Furthermore, the first factor (10 items) indicated the behavioral symptoms of dependence reflecting the extrinsic behaviors of drug seeking. The second factor (9 items) was defined as the impact on social life embodying the impaired severity of social function among drug users. The third factor termed craving (3 items) was used to describe the subjective feeling of spiritual desire of users for drugs. Lastly, the fourth factor termed intention of detoxification (3 items) was interpreted as the intensity of motivation to quit using drugs.

Table 2 Factors and factor loadings of the Chinese and original versions of the API with EFA


In the whole sample, the Cronbach’s alpha correlation coefficient for the total API was 0.914, and its four factors respectively were 0.889, 0.858, 0.555 and 0.690. The MIC of total API was 0.306, ranging from 0.268 (craving) and 0.482 (behavioral symptoms), see Table 4.

Intercorrelation among the API and its four factors

Pearson correlation coefficients of the total score of the API and the four factors ranged from 0.582 to 0.852, see Table 4, and all correlation coefficients between factors were positive and statistically significant (p < 0.01) except for the facets of craving with motivation.

Construct validity and criterion-related validity

As shown in Table 2, two of these 25 items of the revised API loadings on the corresponding factor were inconsistent with the original English version. Thus, the factorial structures of the model developed by Ogel and the newly obtained model were analyzed using CFA in the remaining half of the sample (n = 1126). The results showed that the new model achieved a satisfactory standard and provided the best fit for data on Chinese drug users (RMSEA ≤0.08, TLI ≥0.90, and CFI ≥0.09).

The results of the criterion-related validity showed that the correlation coefficient of the API with its corresponding subscales of other questionnaires ranged from 0.559 to 0.684, the moderate-to-high correlations were positive and significant(p < 0.01), see Table 4.

The measurement equivalence across genders

We performed a multigroup CFA in the total sample to examine whether the scale exhibits measurement invariance across genders (Table 3). In the configural equivalence test, all parameters (i.e. any factor load), as well as the intercept of the observed variables and the residuals were allowed to be freely estimated. The following fitting indices were obtained: TLI = 0.911, CFI = 0.921, and RMSEA = 0.056. When the fitting indices fulfils the criteria of model fit (TLI ≥ 0.9, CFI ≥ 0.9, and RMSEA≤0.08), configural equivalence was established and the configural model was used as the baseline model for subsequent analysis. Equivalent factor loads (same load for the indicator at different measurement points) were set based on the baseline model to verify whether the same item represents the same concept across different groups. The weak equivalence test showed a ΔCFI of 0.002 and a ΔTLI of 0.001. The equivalent of the measurement intercept of each index was set based on the previous step. All fitting indices met the fit criteria: ΔCFI and ΔTLI were 0.01 and 0.007, respectively. Lastly, the error variance equivalent was set on the basis of the third step. The fitting indices suggested that the model can be fitted with a ΔCFI and ΔTLI equal to 0.006 and 0.002, respectively. These results support the assumption that the criterion error variance is equivalent and the strict equivalence equivalent holds.

Table 3 Confirmatory factor analysis of the Addiction Profile Index

The differences in four factors between genders

The t-test was used to compare the differences in four factors of the revised scale across genders among all participants. The results are exhibited in Table 4. Firstly, the results of the independent sample t-test showed that there was no significant difference between the two genders in the score of both the total scale and the craving factor. However, in terms of the behavioral symptoms of the dependence factor, the impact on the social life factor, and the motivation of the detoxification factor, the significant differences were obtained in our study (Table 5).

Table 4 The difference of the API across genders and the correlation coefficient of factors
Table 5 Scores on total API and each of factor separated by gender (Means ± SD)


In current study, we introduced the API. Apart from the analysis of reliability and validity of the Chinese version, the measurement invariance across genders was examined among 2252 drug users.

The 12 items for the addictive substance included information regarding the substances used and the frequency of use, and was termed the characteristics of substance use. According to the major ingredients of a drug as well as the proportion of the population using that drug, the results of demographic data revealed that substances “Magu,” and “Ketamine” should be the new additions. And two items (i.e., “Alcohol” and “Volatile substances”) were deleted as the scale primarily targeted drug users. This classification is similar to that stated in the Diagnostic and Statistical Manual of Mental Disorders, more importantly, it is closely linked to the characteristics of the Chinese drug market [2]. Hence, it is valuable for further research on drug dependence (for further details, see the appendix).

The EFA in the first split-half of the sample showed that the factor of behavioral symptoms of dependence contains two additional items in the present version versus the original version. One of the two items is “Have you ever used (substance) during daytime?”, which belonged to the factor of the effect of substance use on everyday life in the original version. The reason for this difference may be the larger proportion of unemployed participants included in the current study (47.29%). There was no obvious influence on the daily life or work efficiency of the participants even if the drug using occurred during daytime. On the contrary, the level of drug use throughout the day could be used to assess the severity of dependence in individuals in clinical settings [30]. The second item was “Was it difficult for you to resist using (substance) when it was available?”, belonging to the factor of craving in the original version. The factor of craving, also termed psychological craving [31], was described as a subjective feeling from within regarding one’s desire to use a particular substance. From this perspective, we found that the information collected from the three items of the craving factor in the present version basically covered the content of the above definition, such as being reminded of the feeling of pleasure with drug use. However, the factor of behavioral symptoms of dependence reflected a judgement of dependence severity based on individual extrinsically behavioral performance. Furthermore, some researches [32, 33] put forward the notion that different languages and cultural factors could produce distinct factor structures of the scale. From this perspective, the above differentiation of factor structures may be closely related to the linguistic translation of the scale, particularly from the original English to the Chinese version, where semantic and cultural differences in understanding may be inevitable.

Cronbach’s α coefficient was used to verify the internal consistency reliability of the API. DeVellis [23] suggested that a Cronbach’s α coefficient > 0.60 is also considered acceptable. From this perspective, the Cronbach’s α coefficient for the total API and for the three other subscales, except craving, showed a highly significant correlation, reflecting good internal consistency. Regarding the craving factor, the results of the relatively lower alpha coefficient might be related to the relatively fewer items included in this factor [34]. According to Briggs and Nenue [24], the mean inter-item correlation (MIC) was used for reliability estimate in that it is not influenced by scale length, and an optimal range of 0.10–0.50 was set for MIC. Hence, all the mean inter-item coefficients were above the lowest accepted level which also supports the good internal consistency of the API.

For the intercorrelation, Pearson correlation coefficients between the total API and its factors indicated that the validity of the scale is high. Besides, the correlation coefficients between each factor were relatively week. This is consistent with the characteristics of the scale which could independently reflect the different aspects of dependence, provided further support for the validity of the API as a comprehensive measure of drug use experiences.

For criterion-related validity, the results demonstrated that the revised API reaches satisfactory standards (rp = 0.4–0.7) by comparing the scores of four factors and the total API with their corresponding subscales of other questionnaires. Especially, both of the results for the social life and the motivation factor are consistent with the findings reported by Evren in Turkey [17].

Compared with the original version, a single group of CFA showed that the new model fitted the data better among Chinese drug users, which powerfully supported the revised version of the API could be used as the baseline model for subsequent analyses of measurement invariance across genders. Besides, the findings of multigroup CFA indicated the observed scores of the Chinese version of the API have the same meaning across genders, demonstrating that the factor loadings, intercepts, and error variances of each of the items of the revised API are equal, achieving complete equivalence among Chinese drug users. In other words, male and female drug users would respond to each item of the API in a similar manner, and their obtained scores could be directly compared between genders.

Furthermore, we examined the differences between the study’s male and female participants with SUD in terms of their respective scores for the total API as well as its factors, partly following a prior study Diaz-Mesa et al. performed [35]. The significant differences, in respect of behavioral symptoms, social life, and motivation for detoxification, may be associated with gender-determined relative behavioral inhibitory control of the executive function system [36], social roles and responsibilities [37], and personality characteristics [38].


The Chinese version of the Addiction Profile Index shows good psychometric properties in terms of reliability and validity, which could be used to comprehensively assess the severity of dependence in drug users. Furthermore, the measurement invariance and factorial structures of the questionnaire provided more accurate information of gender difference for reference.

Availability of data and materials

All data and materials related to the study can be obtained by contacting the first author at



Addiction Profile Index


Confirmatory factor analysis


Comparative Fit Index


Drug Use Disorders Identification Test


Drug Use Disorders Identification Test-Extended


Exploratory factor analysis


Health Scale for Drug Abuser


Mean inter-item correlations


Root mean square error of approximation


Standardized root mean squared residual


Tucker Lewis Index


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This work was supported by the National Key Research and Development Project (grant number: 2016YFC0800908). In addition, Huiyuan Gao especially wishes to thank Bangpei Zhang, whose encouragement has been giving her powerful spiritual support for the past 2 years.


This research was supported by grants from the National Key Research and Development Project (grant number: 2016YFC0800908).

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TC and JZ contributed equally to this work and are corresponding authors, they designed the study and had overall responsibility for the project; HG conceived the study; JZ, ML, XL, and HG collected data; HG analyzed the data and wrote the first draft of the article; all authors commented on successive drafts, contributed to the interpretation of results, and approved the final version of the article.

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Correspondence to Jun Zhang or Taisheng Cai.

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This study was approved by the Medical Ethics Committee of the Second Xiangya Hospital, Central South University (Changsha, China). All participants provided written informed consents prior to the initiation of the study.

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Table 6 Instruction: please tick the appropriate box according to the actuality of drug using as before. (√)

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Gao, H., Liu, M., Luo, X. et al. Application of the Chinese version of the addiction profile index (API) in drug users: an analysis of validity and measurement invariance across genders. Subst Abuse Treat Prev Policy 15, 28 (2020).

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