Skip to main content

Physical pain is common and associated with nonmedical prescription opioid use among people who inject drugs



People who inject drugs (PWID) often have poor health and lack access to health care. The aim of this study was to examine whether PWID engage in self-treatment through nonmedical prescription opioid use (NMPOU). We describe the prevalence and features of self-reported physical pain and its association with NMPOU.


PWID (N = 702) in San Francisco, California (age 18+) were recruited to complete interviewer administered surveys between 2011 and 2013. Multivariate logistic regression analysis was conducted to examine the associations among self-reported pain dimensions (past 24-h average pain, pain interference with functional domains) and NMPOU, controlling for age, sex, psychiatric illness, opioid substitution treatment, homelessness, street heroin use and unmet healthcare needs.


Almost half of the sample reported pain, based on self-reported measures in the 24 h before their interview. The most common pain locations were to their back and lower extremities. Past 24-h NMPOU was common (14.7%) and associated with past 24 h average pain intensity on a 10 point self-rating scale (adjusted odds ratio [AOR] = 2.15, 95% confidence interval [CI] 1.21–3.80), and past 24 h pain interference with general activity (AOR 1.82 [95% CI 1.04–3.21]), walking ability (AOR 2.52 [95% CI 1.37–4.63]), physical ability (AOR 2.01 [95% CI 1.16–3.45]), sleep (AOR 1.98 [95% CI 1.13–3.48]) and enjoyment of life (AOR 1.79 [95% CI 1.02–3.15]).


Both pain and NMPOU are common among PWID, and highly correlated in this study. These findings suggest that greater efforts are needed to direct preventive health and services toward this population.


The nonmedical use of prescription opioids (NMPOU) has received considerable attention in the United States. Despite attention by the research and public policy communities, it is not surprising that the term “nonmedical use” has developed different definitions and usage within these different stakeholder communities [1]. It has been defined as ‘use without a prescription of the individual’s own or simply for the experience or feeling the drug caused’ [2]. However, it also has been described as misuse to get high, and as self-treatment for perceived physical or psychiatric problems [3, 4]. Most national surveys, such as the National Survey on Drug Use and Health (NSDUH) [5] and Monitoring the Future [6], combine both self-treatment and euphoric use into a single category. This definition masks important differences in terms of why individuals engage in NMPOU.

NMPOU has been described as a crisis by US public health authorities [7, 8] because of the dramatic increases in overdoses and substance abuse treatment admissions associated with opioid use [9]. Data from national studies indicate that NMPOU remains highly prevalent, despite recent efforts to control the prescriptions and diversion of medications to others [10, 11]. NSDUH estimates that in 2014, 1.6% of the U.S. population aged 12 years or older had been using prescription analgesics nonmedically in the past month [5]. These data also consistently show that opioids are the most common prescription drugs used nonmedically.

NMPOU has been linked to numerous adverse health-related consequences, largely due to its depressogenic effects on numerous biological systems, including the central nervous system causing somnolence or even unconsciousness and suppressing respiratory activity, and bowel and lower GI tract (e.g., opioid induced constipation). People who use prescription opioids nonmedically are sometimes also injecting drugs, which is critical from a public health standpoint, because of harms associated with injections such as venous scarring and infectious diseases [12, 13].

It is well documented that people who inject drugs (PWID) often lack stable employment and have inconsistent lines of income [14]. This economic instability means that PWID are often ineligible for government economic subsidies, including employer sponsored health insurance. PWID also experience unstable housing [15, 16] which complicates their ability to achieve a medical home that can provide consistent preventive and acute care. Overall, the highly unstable environment of PWID contributes to poor health and nutrition status, both of which may increase the risk of physical pain related to both chronic and acute conditions [17,18,19,20]. There is a longstanding tradition of research on documenting the prevalence of physical pain in general population surveys. Unfortunately, few studies have focused on physical pain in PWID. The limited studies suggest that chronic pain is highly prevalent. In studies by Tsui et al. [21] and Heimer et al. [22], one-third of PWID reported chronic pain. High prevalence of venous insufficiency, causing chronic leg pain, has been shown in PWID [23, 24].

A few large-scale studies have investigated the association among physical pain and NMPOU. Novak et al. [25] showed a positive linear correlation between the level of self-reported pain interference and the likelihood of past year NMPOU in the general North American population. The study further showed that self-reported pain was an independent risk factor for NMPOU, yet its effects were substantially modified by patterns of substance use. A survey of the general population in Sweden showed that more days with poor self-assessed physical health were significantly associated with NMPOU, but not with the nonmedical use of sedatives [26]. Besides these studies, research on NMPOU and its associations with pain is sparse, and studies are conducted mostly in outpatient populations receiving chronic opioid therapy. A meta-analysis by Fishbain et al. [27] showed that a diagnosis of drug abuse, drug dependence or drug addiction was present in 3%-19% of persons with chronic pain. Back pain and multiple pain complaints were factors identifying patients in chronic opioid therapy at high risk for misuse [28]. Other studies of patients with chronic pain showed no association between pain score and NMPOU [29, 30]. A recent longitudinal study by Martel et al. [31] showed that high level of pain was only weakly associated with opioid craving among patients with chronic pain.

A notable gap in the literature is that few studies have investigated the relationship between different dimensions of pain and NMPOU, particularly among high-risk populations who contend with high levels of pain such as PWID. There have been some studies that have explored rather course measures of self-reported pain. For example, Khosla et al. found a positive association between pain and a single measure of any type of nonmedical prescription drug use (NMPD) in American PWID [32]. The authors found that NMPD among PWID was significantly associated with self-reported bodily pain and pain interference with activity, and also with the hazardous use of alcohol, use of illicit substances, and active injection drug use. Misuse of prescription analgesics was the most common type of NMPD (17% reported opiate use in the past 6 months). However, a limitation of this prior work is that pain was assessed with a single item or that pain interference was concerning global functioning. To our knowledge, no studies have examined the relationship between distinct aspects of pain (e.g., location, duration and severity) and NMPOU.

The current paper provides a more refined examination between pain and NMPOU. A primary aim is to, in a sample consisting solely of PWID, describe the prevalence of recent physical pain, pain duration, pain intensity and pain interference. Then, a second aim is to characterize subgroups at differential impairment and functioning related to pain and investigate the association between NMPOU and pain-related factors.


Study sample and procedures

The study sample for this cross-sectional study comprised 706 PWID in San Francisco, California, with the data collected between November of 2011 and March of 2013. Potential participants were recruited from community settings using targeted sampling methods [33,34,35]. Three community field sites, located in neighborhoods near large populations of PWID, were utilized to conduct the interviews. Eligibility criteria included injection drug use in the past 30 days as verified by checking for recent signs of venipuncture, being 18 years of age or older, and the ability to provide informed consent [36]. Four persons were interviewed as part of the study, but whose data were later excluded because they answered on the survey that they had not injected drugs in the past 30 days. The survey was administered by a trained interviewer, and lasted between 45 and 60 min. Study participants received $20 (USD) for completing the interview. All study procedures were approved by the Institutional Review Board at RTI International.

Instruments and measures

Outcome variable

The outcome variable was NMPOU past 24 h. The definition used the stem from the National Survey on Drug Use and Health, noting that “The next questions are about drugs that are typically prescribed by physicians. We are interested in your use of these medications without a doctor's prescription and your use of these medications not as directed by your physician.”

NMPOU past 24 h was assessed through the question “When was the last time you used [prescription analgesic]?” All persons who replied “within the past 24 h” (multiple choice question) for any of the following prescription analgesics (assessed separately) were recoded as ‘NMPOU past 24 h’: Vicodin, Oxycontin, Oxycodone, Percocet, Dilaudid, Fentanyl, Tramadol, Morphine, Embeda, Roxicodone, Opana, and other (Specify). We also included those who reported past 24 h nonmedical use of methadone, buprenorphine or Suboxone, i.e. those who replied “within the past 24 h” to any of the multiple choice questions “When was the last time you used [Methadone/Buprenorphine or Suboxone] (not prescribed directly to you by a doctor or from a clinic, or the prescription was for you, but you took more than the Dr. prescribed)?

Explanatory variables

Explanatory variables were pain intensity, pain location, pain duration, and pain interference. Recent pain prevalence was measured using the yes/no question “Have you had pain in the past 24 hours? Please include pain that might be masked by your drug or alcohol use.” Pain intensity, and pain interference with general activity, mood, walking ability, physical ability, relationships, sleep and enjoyment of life were assessed using a modified version of the Brief Pain Inventory [37], which uses numeric scales where 0 was ‘no pain’ or ‘does not interfere’ and 10 was ‘pain as bad as you can imagine’ or ‘completely interferes.’ The Brief Pain Inventory, which has been widely used in studies measuring pain in substance-using populations [38,39,40], is validated for neuropathic pain [37] and is highly sensitive for pain assessment in patients in opioid substitution therapy [41]. The variables were recoded into three categories: 0 = no pain/interference (i.e. those who rated their pain/interference as 0 + those who didn’t have pain at all the past 24 h); 1 = pain/interference score from 1 to median; and 2 = pain/interference score above median. Since clinically relevant cut-off values for levels of pain and pain interference are difficult to estimate in this population, and the pain measurement values were not expected to follow a normal distribution, we dichotomized the values at the median. Median was calculated only for values 1–10 (0 excluded). The same procedure was conducted for pain duration. Missing data was recoded as ‘no pain reported (0)’ The rationale is that any person who skipped this item is likely doing so because they misinterpreted the item and felt they had no pain to report. Missing values did not exceed n = 3 for any of the variables.

For pain location, the study participants were provided a body chart that outlined 45 separate regions. The instructions of the inventory started with the instructions, “Please look at the diagram and point to the area of your body that hurts the most.” Several answers were allowed. We recoded the areas checked in the questions above into seven categories according to clinical relevance; head, neck and shoulders, back, upper extremities, lower extremities, abdomen, and genitals. Worst pain location was assessed through the question “Which of the areas of your body is causing you the most pain?” Responses according to the body chart were recoded into four mutually exclusive areas: head, neck/shoulders/back, extremities (upper and lower limbs), and abdomen/genitals. Where the response to this question was missing (n = 103), recoding into one of the four areas above was conducted if the subject had checked only one painful area for the question “Please look at the diagram and point to the area of your body that hurts the most.” Using this procedure, we were able to classify 99 individuals into one of four locations. If the subject had checked several painful areas (i.e. responses that could not be recoded into only one of four mutually exclusive areas), the subject was excluded from statistical analyses (n = 4).


Based on the literature identifying associations between NMPOU and other substance use [25, 26, 29, 30, 42] and psychiatric disorders [26, 29, 42], we controlled all multivariate analyses for the following variables: Age at interview (left in its original metric) [28, 30]; biological sex at birth (male or female) [26, 30]; homelessness; lifetime psychiatric illness; use of street heroin; recent opioid substitution treatment (OST); and unmet healthcare needs.

Current homelessness was defined as a ‘yes’ to the question “Do you consider yourself to be homeless?”. Lifetime psychiatric disorder was defined as a ‘yes’ to the question “As an adult, have you ever been diagnosed with a psychiatric illness (e.g., major depression, bipolar disorder)?” Use of street heroin in the past 24 h was defined as replying “Within the past 24 h” to the question “When was the last time you used [drug]?” for any of the drugs speedball (heroin/cocaine, heroin/crack), goofball (heroin/methamphetamine) or heroin. Note that we did not discriminate routes of administration. OST in the past 30 days was defined as replying ‘yes’ to any of the questions “Have you participated in methadone maintenance in the past 30 days?” or “In the past 30 days have you participated in buprenorphine (Suboxone) treatment?”.

Unmet healthcare needs in the past 6 months was also included as a covariate. All subjects who replied ‘no’ to all three questions “In the past 6 months did you need care for an urgent health problem such as an abscess, strep throat or the flu?”, “In the past 6 months did you need care for an ongoing health problem (e.g. high blood pressure, diabetes)?”, and “In the past 6 months did you need dental care?” were recoded as ‘No need for healthcare in the past 6 months’. All subjects who reported need of any healthcare, and replied ‘no’ to either the question “In the past 6 months, did you try to get [healthcare]?” or the question “In the past 6 months, have you received [healthcare]?” were recoded as ‘Unmet health care need in the past 6 months’. All remaining subjects who were neither recoded as ‘No need for healthcare in the past 6 months’ nor ‘Unmet health care need in the past 6 months’ were recoded as ‘Met healthcare need in the past 6 months.’

The number of covariates in multivariate analysis was limited to one per 10 cases. Missing data values were recoded as ‘no’ (0). The number of missing values did not exceed n = 3 for any of the variables.

Statistical analysis

We first started by estimating the bivariate associations between each of the 11 pain variables described above and NMPOU. We restricted the reporting window to the past 24 h. All variables were binary or categorical, and for statistical testing significance, we used unadjusted logistic regression analysis for binary outcomes. Multivariate logistic regression analysis was conducted with pain variables associated with NMPOU past 24 h at level p < 0.05 in bivariate analysis, adjusted for all pre-defined covariates. A correlation analysis was performed to prevent inclusion of explanatory variables and covariates with correlation 0.7 or more from the same analysis. P-values below 0.05 for a two-tailed test were considered statistically significant. All statistical analyses were performed in SPSS version 21.0 [43].


Sample characteristics

Seven hundred and two PWID were included in the study. Twenty-one percent were female (Table 1). Mean age was 45.1 years (range 18–69). The most common street drugs used in the past 24 h were marijuana (36.8%), methamphetamine (27.6%) and heroin (24.6%). Fifteen percent (n = 103) reported NMPOU (including methadone and buprenorphine) in the past 24 h.

Table 1 Sample characteristics among people who inject drugs in San Francisco, for total sample (N = 702) and subjects reporting past 24 h pain (n = 335)

Pain characteristics

Slightly less than half of the study participants, 47.7% (n = 335) reported that they had physical pain in the past 24 h (Table 2). Median pain duration was 36 months (interquartile range [IQR] 6–141 months). The most common pain locations were lower limbs (27.1%) and back (19.7%). Median average pain in the past 24 h was six on a 10-point scale (IQR 5–7). Approximately 40% of the sample reported past 24 h pain interference with the functional domains presented in Table 2.

Table 2 Pain prevalence and association with use of nonmedical prescription opioid use in the past 24 h among people who inject drugs in San Francisco (N = 702). Bivariate logistic regression analysis

Associations between pain and NMPOU

In bivariate analysis, scores above median of pain intensity (average pain in past 24 h) and past 24 h level of pain interference with general activity, walking ability, physical ability, sleep and enjoyment of life were significantly and positively associated with NMPOU past 24 h (Table 2). Pain duration, pain location, and pain interference with mood and relationships were not statistically associated with NMPOU. After correlation analysis showing over 0.7 level correlation between all pain-related candidate variables, we conducted separate multivariate analyses assessing the association of each pain variable with NMPOU past 24 h. None of the covariates were excluded due to collinearity.

In multivariate analysis adjusted for age, sex, lifetime psychiatric diagnosis, homelessness, past 30 days OST, past 24 h use of street heroin and unmet healthcare needs in the past 6 months, NMPOU past 24 h was independently and positively associated with all the pain variable associated with NMPOU in bivariate analysis (Table 3).

Table 3 Multivariate logistic regression analysis of nonmedical prescription opioid use among people who inject drugs in San Francisco (N = 702). Outcome variable: NMPOU past 24 h


The current study found that both pain and NMPOU were common among PWID, a high-risk population that traditionally lacks access to health care. The findings showing several independent cross-sectional associations between NMPOU and levels of pain and pain interference among PWID are novel and have important clinical implications.

Both recent and long-term pain was common in the study sample, which is similar to the sparse previous research on pain among PWID. Among HIV-positive patients, those who inject drugs have been shown to report more pain than those who do not inject drugs [44, 45]. Also, the prevalence of chronic pain is high among opioid dependent persons in opioid substitution treatment [46]. In one study, 37% reported chronic severe pain [40], and in another 61% reported chronic pain problems [47]. This high pain prevalence is not surprising, considering that homelessness, poverty and several potentially painful conditions such as dental problems [48], abscesses [49,50,51], other injection-related injuries [52] and chronic wounds [53] are common among PWID.

The primary contribution of this study was that we examined a diverse range of pain-related characteristics. While there was no statistically significant difference regarding NMPOU between subjects reporting no pain in the past 24 h and average pain median or below on the 10-point modified Brief Pain Inventory scale, subjects reporting average pain intensity above the median had more than doubled odds for NMPOU. Conversely, there was no association between NMPOU and pain duration. The association between pain intensity and NMPOU was similar to the results from surveys in the general American population study of non-institutionalized persons aged 18 or older showing a positive linear correlation between level of pain and past year NMPOU [25], but counter to previous research, which have not showed an association between pain and NMPOU in non-PWID cohorts consisting of U.S. veterans [29] and patients with chronic pain [30]. Given that we limited our measures to pain in the past 24 h, it is not surprising that we observed that pain was associated with NMPOU at the event-level over the previous day. Additional studies, perhaps using event-driven sampling like ecological momentary analysis, would be helpful in understanding the linkages between the onset of pain and NMPOU as a means to self-medicate pain.

We also observed that pain interference above median with general activity, walking ability, physical ability, sleep, and enjoyment of life was independently and positively associated with recent NMPOU.

Back pain and lower extremity pain was common in the study sample of PWID. This finding follows a study by Barry et al. [54] showing that chronic pain among persons seeking OST was most commonly located in back or legs. Lower extremity pain is common among PWID and homeless people, due to dermatological problems [55, 56], foot trauma and venous disorders [23, 24]. These pain locations are not notably different from what could be expected in the general population [57,58,59,60]. We did not find any significant association between pain location and NMPOU past 24 h, which is consistent with previous studies [29].

While the cross-sectional design of this study allows no interpretation of causality, our findings imply that PWID who use prescription pain relievers non-medically may be attempting to self-medicate or manage pain problems. Self-medication of pain, with heroin or prescription opioids, has been shown to be prevalent in 98% of PWID with moderate or extreme pain [61] and associated with being denied prescription analgesics. However, Heimer et al. [22] showed that four out of five PWID with chronic pain reported NMPOU before debut of their pain. In addition, up to three-quarters of patients with chronic non-cancer pain have been shown to have a lifetime history of substance use disorder [62]. Co-occurrence of pain and nonmedical substance use appears to be a complex matter, and future, longitudinal studies are necessary to assess causal relationships.

Covariates positively associated with NMPOU were younger age, use of street heroin, and unmet healthcare needs. Interestingly, recent use of street heroin was strongly associated with recent NMPOU in this study, while OST was not. Since all subjects in the study were PWID currently using drugs intravenously, this finding allows no interpretation regarding OST as a potential protective factor for avoiding NMPOU. However, future research assessing OST to diminish NMPOU would be of great clinical relevance. Worth noting is also that over half of the population had unmet healthcare needs in the past 6 months. We recommend future studies assessing unmet healthcare needs specifically as a predictor of NMPOU.

This study has several limitations that should be noted. All results were based on self-reports, and no structured clinical diagnosis or drug testing has been performed. We are unsure how the self-reported nature of the data on pain may bias our results, given that pain cannot be objectively measured. We believe that recall bias is kept to a minimum since the pain-related questions and the prescription and street drug questions were mostly about the past 24 h. The possibility of social desirability bias affecting the study participants’ reports of pain and drug use/NMPOU should, however, not be neglected. One additional limitation is that power was low to detect differences in pain as it related to NMPOU. We restricted our time-frame for most of our analyses to the past 24 h. This was done to boost our ability to link the timeframe in which pain could be self-mediated by prescription opioids. Unfortunately, a consequence of this decision was that there were a small number of cases that engaged in NMPOU during that timeframe. If we had expanded the window to the past 30 days, we would have gained statistical power by increasing the number of cases that endorsed NMPOU, but since most of the pain variables in the questionnaire were assessing past 24 h pain, we did not include past 30 days NMPOU data. Since temporality of pain and NMPOU could not assess in this cross-sectional study, reverse causality could not be excluded. It would thus be interesting to conduct longitudinal studies to examine whether individuals began NMPOU because of self-management, and then through habituation became tolerant of opioids. Neither physical comorbidity nor current psychiatric illness was possible to control for, which is an important limitation due to the large body of research data showing overlap between psychiatric morbidity and substance use [26, 29, 42].

The clinical implications of the present study are such that medical care is needed to address the high demand medical health needs of the PWID populations. Recently, several insurance companies in the United States have announced reductions in the patient coverage for opioid use as a means to reduce NMPOU [63, 64]. This complicates the situation for PWID, who already are disenfranchised from medical care and pain relief that could ease their pain and suffering, and there is a concern that prescribing restrictions might limit pain medication acquisition among legitimate pain patients. Previous research on pain management among vulnerable populations has identified inadequate analgesic therapy among 85% of patients with AIDS, and especially among AIDS-patients who were female, low-educated or PWID [65]. Voon et al. [66] showed that two-thirds of 462 PWID had ever been denied prescription analgesics, while 92% reported lifetime disability. Additional research is needed to determine whether or not these policies may have adverse impacts on PWID, including further removal from the main-stream medical system, or whether policies like the Affordable Health Care Act or similar reforms can serve to re-introduce those who have traditionally been excluded from the medical system.


In conclusion, both pain and NMPOU were common among PWID, and pain intensity and pain interference were positively associated with NMPOU in this group. These findings implicate a strong need for improved physical healthcare among PWID. There is also a need for future longitudinal studies assessing the temporal nature of the associations between pain indicators and NMPOU, and evaluations of potential consequences of policies that restrict access to prescription opioids for high-risk populations including PWID.


  1. Boyd CJ, McCabe SE. Coming to terms with the nonmedical use of prescription medications. Subst Abuse Treat Prev Policy. 2008;3:22.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Substance Abuse and Mental Health Services Administration (SAMHSA). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. NSDUH Series H-41, HHS Publication No. (SMA) 11-4658. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2011. Retrieved 5/10/2016 from Accessed 28 May 2017.

  3. Hernandez SH, Nelson LS. Prescription drug abuse: insight into the epidemic. Clin Pharmacol Ther. 2010;88(3):307–17.

    Article  CAS  PubMed  Google Scholar 

  4. Barrett SP, Meisner JR, Stewart SH. What constitutes prescription drug misuse? Problems and pitfalls of current conceptualizations. Curr Drug Abuse Rev. 2008;1(3):255–62.

    Article  PubMed  Google Scholar 

  5. Center for Behavioral Health Statistics and Quality. Behavioral health trends in the United States: Results from the 2014 National Survey on Drug Use and Health (HHS Publication No. SMA 15-4927, NSDUH Series H-50). 2015. Retrieved 5/10/16 from Accessed 28 May 2017.

  6. Johnston LD, O’Malley PM, Miech RA, Bachman JG, Schulenberg JE. Monitoring the future national survey results on drug use: 1975-2014: overview, key findings on adolescent drug use. Ann Arbor: Institute for Social Research, The University of Michigan; 2015.

    Google Scholar 

  7. Tavernise S. C.D.C. painkiller guidelines aim to reduce addiction risk. New York Times. March 15 2016. Retrieved 10/03/2016 from

  8. Office of National Drug Control Policy (ONDCP). Epidemic: Responding to America's prescription drug abuse crisis. 2011. Retrieved 09/26/2016 from Accessed 28 May 2017.

  9. Muhari P, Gfroerer J, Davies C. CBHSQ data review: Associations of nonmedical prescription pain reliever use and initiation of heroin use in the United States. August 2013. Retrieved 10/03/2016 from

  10. Reifler LM, Droz D, Bailey JE, Schnoll SH, Fant R, Dart RC, et al. Do prescription monitoring programs impact state trends in opioid abuse/misuse? Pain Med. 2012;13(3):434–42.

    Article  PubMed  Google Scholar 

  11. Fain KM, Alexander GC. Disposing of medicines safely. Am J Public Health. 2014;104(12):e2–3.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wurcel AG, Merchant EA, Clark RP, Stone DR. Emerging and Underrecognized complications of illicit drug use. Clin Infect Dis. 2015;61(12):1840–9.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Larney S, Peacock A, Mathers BM, Hickman M, Degenhardt L. A systematic review of injecting-related injury and disease among people who inject drugs. Drug Alcohol Depend. 2017;171:39–49.

    Article  PubMed  Google Scholar 

  14. Heimer R, Barbour R, Palacios WR, Nichols LG, Grau LE. Associations between injection risk and community disadvantage among suburban injection drug users in southwestern Connecticut, USA. AIDS Behav. 2014;18(3):452–63.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lloyd-Smith E, Kerr T, Hogg RS, Li K, Montaner JS, Wood E. Prevalence and correlates of abscesses among a cohort of injection drug users. Harm Reduct J. 2005;2:24.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Lloyd-Smith E, Wood E, Zhang R, Tyndall MW, Montaner JS, Kerr T. Risk factors for developing a cutaneous injection-related infection among injection drug users: a cohort study. BMC Public Health. 2008;8:405.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Bruggmann P, Grebely J. Prevention, treatment and care of hepatitis C virus infection among people who inject drugs. Int J Drug Policy. 2015;26(Suppl 1):S22–6.

    Article  PubMed  Google Scholar 

  18. Coffin PO, Jin H, Huriaux E, Mirzazadeh A, Raymond HF. Trends in use of health care and HIV prevention services for persons who inject drugs in San Francisco: results from national HIV behavioral surveillance 2005-2012. Drug Alcohol Depend. 2015;146:45–51.

    Article  PubMed  Google Scholar 

  19. Lorvick J, Kral AH, Seal K, Gee L, Edlin BR. Prevalence and duration of hepatitis C among injection drug users in San Francisco, Calif. Am J Public Health. 2001;91(1):46–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Badiaga S, Raoult D, Brouqui P. Preventing and controlling emerging and reemerging transmissible diseases in the homeless. Emerg Infect Dis. 2008;14(9):1353–9.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Tsui JI, Herman DS, Kettavong M, Anderson BJ, Stein MD. Chronic pain and hepatitis C virus infection in opioid dependent injection drug users. J Addict Dis. 2011;30(2):91–7.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Heimer R, Zhan W, Grau LE. Prevalence and experience of chronic pain in suburban drug injectors. Drug Alcohol Depend. 2015;151:92–100.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Pieper B, Templin T. Lower extremity changes, pain, and function in injection drug users. J Subst Abus Treat. 2003;25(2):91–7.

    Article  Google Scholar 

  24. Pieper B, Kirsner RS, Templin TN, Birk TJ. Injection drug use: an understudied cause of venous disease. Arch Dermatol. 2007;143(10):1305–9.

    Article  PubMed  Google Scholar 

  25. Novak SP, Herman-Stahl M, Flannery B, Zimmerman M. Physical pain, common psychiatric and substance use disorders, and the non-medical use of prescription analgesics in the United States. Drug Alcohol Depend. 2009;100(1-2):63–70.

    Article  PubMed  Google Scholar 

  26. Abrahamsson T, Hakansson A. Nonmedical prescription drug use (NMPDU) in the Swedish general population-correlates of analgesic and sedative use. Subst Use Misuse. 2015;50(2):148–55.

    Article  PubMed  Google Scholar 

  27. Fishbain DA, Rosomoff HL, Rosomoff RS. Drug abuse, dependence, and addiction in chronic pain patients. Clin J Pain. 1992;8(2):77–85.

    Article  CAS  PubMed  Google Scholar 

  28. Sullivan MD, Edlund MJ, Fan MY, Devries A, Brennan Braden J, Martin BC. Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans: the TROUP study. Pain. 2010;150(2):332–9.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Edlund MJ, Steffick D, Hudson T, Harris KM, Sullivan M. Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. Pain. 2007;129:355–62.

    Article  PubMed  Google Scholar 

  30. Ives TJ, Chelminski PR, Hammett-Stabler CA, Malone RM, Perhac JS, Potisek NM, et al. Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res. 2006;6:46.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Martel MO, Finan PH, McHugh RK, Issa M, Edwards RR, Jamison RN, et al. Day-to-day pain symptoms are only weakly associated with opioid craving among patients with chronic pain prescribed opioid therapy. Drug Alcohol Depend. 2016;162:130–6.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Khosla N, Juon HS, Kirk GD, Astemborski J, Mehta SH. Correlates of non-medical prescription drug use among a cohort of injection drug users in Baltimore City. Addict Behav. 2011;36(12):1282–7.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Watters JK, Biernacki P. Targeted sampling: options for the study of hidden populations. Soc Probl. 1989;36(4):416–30.

    Article  Google Scholar 

  34. Bluthenthal RN, Watters JK. Multimethod research from targeted sampling to HIV risk environments. NIDA Res Monogr. 1995;157:212–30.

    CAS  PubMed  Google Scholar 

  35. Kral AH, Malekinejad M, Vaudrey J, Martinez AN, Lorvick J, McFarland W, et al. Comparing respondent-driven sampling and targeted sampling methods of recruiting injection drug users in San Francisco. J Urban Health. 2010;87(5):839–50.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Dahlman D, Håkansson A, Kral AH, Wenger L, Ball EL, Novak SP. Behavioral characteristics and injection practices associated with skin and soft tissue infections among people who inject drugs: a community-based observational study. Subst Abus. 2017;38(1):105–12.

    Article  PubMed  Google Scholar 

  37. Zelman DC, Gore M, Dukes E, Tai KS, Brandenburg N. Validation of a modified version of the brief pain inventory for painful diabetic peripheral neuropathy. J Pain Symptom Manag. 2005;29(4):401–10.

    Article  Google Scholar 

  38. Breitbart W, Rosenfeld B, Passik S, Kaim M, Funesti-Esch J, Stein K. A comparison of pain report and adequacy of analgesic therapy in ambulatory AIDS patients with and without a history of substance abuse. Pain. 1997;72(1-2):235–43.

    Article  CAS  PubMed  Google Scholar 

  39. Passik SD, Kirsh KL, Donaghy KB, Portenoy RK. Pain and aberrant drug-related behaviors in medically ill patients with and without histories of substance abuse. Clin J Pain. 2006;22(2):173–81.

    Article  PubMed  Google Scholar 

  40. Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003;289(18):2370–8.

    Article  PubMed  Google Scholar 

  41. Dennis BB, Roshanov PS, Bawor M, Paul J, Varenbut M, Daiter J, et al. Usefulness of the brief pain inventory in patients with Opioid addiction receiving methadone maintenance treatment. Pain Physician. 2016;19(1):E181–95.

    PubMed  Google Scholar 

  42. Edlund MJ, Martin BC, Fan MY, Devries A, Braden JB, Sullivan MD. Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. Drug Alcohol Depend. 2010;112(1-2):90–8.

    Article  PubMed  PubMed Central  Google Scholar 

  43. IBM Corp. Released 2012. IBM SPSS statistics for windows, version 21.0. Armonk: IBM Corp.

  44. Del Borgo C, Izzi I, Chiarotti F, Del Forno A, Moscati AM, Cornacchione E, et al. Multidimensional aspects of pain in HIV-infected individuals. AIDS Patient Care STDs. 2001;15(2):95–102.

    Article  CAS  PubMed  Google Scholar 

  45. Martin C, Pehrsson P, Österberg A, Sönnerborg A, Hansson P. Pain in ambulatory HIV-infected patients with and without intravenous drug use. Eur J Pain. 1999;3(2):157–64.

    Article  CAS  PubMed  Google Scholar 

  46. Voon P, Hayashi K, Milloy MJ, Nguyen P, Wood E, Montaner J, et al. Pain among high-risk patients on methadone maintenance treatment. J Pain. 2015;16(9):887–94.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Jamison RN, Kauffman J, Katz NP. Characteristics of methadone maintenance patients with chronic pain. J Pain Symptom Manag. 2000;19(1):53–62.

    Article  CAS  Google Scholar 

  48. Robbins JL, Wenger L, Lorvick J, Shiboski C, Kral AH. Health and oral health care needs and health care-seeking behavior among homeless injection drug users in San Francisco. J Urban Health. 2010;87(6):920–30.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Ivan M, van Beek I, Wand H, Maher L. Surveillance of injecting-related injury and diseases in people who inject drugs attending a targeted primary health care facility in Sydney's kings cross. Aust N Z J Public Health. 2015;39(2):182–7.

    Article  PubMed  Google Scholar 

  50. Phillips KT, Stein MD. Risk practices associated with bacterial infections among injection drug users in Denver, Colorado. Am J Drug Alcohol Abuse. 2010;36(2):92–7.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Pollini RA, Gallardo M, Hasan S, Minuto J, Lozada R, Vera A, et al. High prevalence of abscesses and self-treatment among injection drug users in Tijuana, Mexico. Int J Infect Dis. 2010;14(Suppl 3):e117–22.

    Article  PubMed  Google Scholar 

  52. Roose RJ, Hayashi AS, Cunningham CO. Self-management of injection-related wounds among injecting drug users. J Addict Dis. 2009;28(1):74–80.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Smith ME, Robinowitz N, Chaulk P, Johnson KE. High rates of abscesses and chronic wounds in community-recruited injection drug users and associated risk factors. J Addict Med. 2015;9(2):87–93.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Barry DT, Beitel M, Joshi D, Schottenfeld RS. Pain and substance-related pain-reduction behaviors among opioid dependent individuals seeking methadone maintenance treatment. Am J Addict. 2009;18(2):117–21.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Stratigos AJ, Stern R, González E, Johnson RA, O'Connell J, Dover JS. Prevalence of skin disease in a cohort of shelter-based homeless men. J Am Acad Dermatol. 1999;41(2 Pt 1):197–202.

    Article  CAS  PubMed  Google Scholar 

  56. Raoult D, Foucault C, Brouqui P. Infections in the homeless. Lancet Infect Dis. 2001;1(2):77–84.

    Article  CAS  PubMed  Google Scholar 

  57. Hoy D, Bain C, Williams G, March L, Brooks P, Blyth F, et al. A systematic review of the global prevalence of low back pain. Arthritis Rheum. 2012;64(6):2028–37.

    Article  PubMed  Google Scholar 

  58. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81(9):646–56.

    PubMed  PubMed Central  Google Scholar 

  59. Manchikanti L, Singh V, Falco FJ, Benyamin RM, Hirsch JA. Epidemiology of low back pain in adults. Neuromodulation. 2014;17(Suppl 2):3–10.

    Article  PubMed  Google Scholar 

  60. Thiem U, Lamsfuß R, Günther S, Schumacher J, Bäker C, Endres HG, et al. Prevalence of self-reported pain, joint complaints and knee or hip complaints in adults aged ≥ 40 years: a cross-sectional survey in Herne, Germany. PLoS One. 2013;8(4):e60753.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Voon P, Callon C, Nguyen P, Dobrer S, Montaner J, Wood E, et al. Self-management of pain among people who inject drugs in Vancouver. Pain Manag. 2014;4(1):27–35.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Morasco BJ, Gritzner S, Lewis L, Oldham R, Turk DC, Dobscha SK. Systematic review of prevalence, correlates, and treatment outcomes for chronic non-cancer pain in patients with comorbid substance use disorder. Pain. 2011;152(3):488–97.

    Article  PubMed  Google Scholar 

  63. Cigna. Cigna outlines steps to help curb national drug epidemic. May 19 2016. Retrieved 05/25/2016 from Accessed 28 May 2017.

  64. Coghlan, E. Opioid Prescriptions Drop – Cigna To Reduce Further. Posted on May 21, 2016 in Drug Addiction, Pain Medication. Retreived 3/6/2016 from

  65. Breitbart W, Rosenfeld BD, Passik SD, McDonald MV, Thaler H, Portenoy RK. The undertreatment of pain in ambulatory AIDS patients. Pain. 1996;65(2-3):243–9.

    Article  CAS  PubMed  Google Scholar 

  66. Voon P, Callon C, Nguyen P, Dobrer S, Montaner JS, Wood E, et al. Denial of prescription analgesia among people who inject drugs in a Canadian setting. Drug Alcohol Rev. 2015;34(2):221–8.

    Article  PubMed  Google Scholar 

Download references


The authors gratefully acknowledge the study participants for sharing their time and life histories with our research team hoping to learn about the disease of addiction. The authors also wish to thank Daria Garina, John McGaffie and Jahaira Fajardo who conducted the field interviews, and Nathaniel Rodman for instrumentation and programming.


This study was funded by a grant from the National Institute on Drug Abuse (DA #R01DA030427, PI. Novak).

Availability of data and materials

The datasets used and analyzed during the study available from the corresponding author on reasonable request.

Authors’ contributions

The research was conducted as part of a larger interview study where the last author, Scott P. Novak (Ph.D.) was the principal investigator. The first author, DD (MD, MA, Ph.D. candidate) wrote the manuscript and conducted the data with input from the other three authors. SPN, AHK, and LW were responsible for study design. All authors were part of completing the manuscript. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

All study procedures were approved by the Institutional Review Board at RTI International. All study participants provided informed consent.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Disa Dahlman.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dahlman, D., Kral, A.H., Wenger, L. et al. Physical pain is common and associated with nonmedical prescription opioid use among people who inject drugs. Subst Abuse Treat Prev Policy 12, 29 (2017).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: