Physical pain is common and associated with nonmedical prescription opioid use among people who inject drugs

The nonmedical use of prescription opioids (NMPOU) has received considerable attention in the United States. Despite attention by the research and public policy communities, it is not surprising that the term “nonmedical use” has developed different definitions and usage within these different stakeholder communities [1]. It has been defined as ‘use without a prescription of the individual’s own or simply for the experience or feeling the drug caused’ [2]. However, it also has been described as misuse to get high, and as self-treatment for perceived physical or psychiatric problems [3, 4]. Most national surveys, such as the National Survey on Drug Use and Health (NSDUH) [5] and Monitoring the Future [6], combine both self-treatment and euphoric use into a single category. This definition masks important differences in terms of why individuals engage in NMPOU.

NMPOU has been described as a crisis by US public health authorities [7, 8] because of the dramatic increases in overdoses and substance abuse treatment admissions associated with opioid use [9]. Data from national studies indicate that NMPOU remains highly prevalent, despite recent efforts to control the prescriptions and diversion of medications to others [10, 11]. NSDUH estimates that in 2014, 1.6% of the U.S. population aged 12 years or older had been using prescription analgesics nonmedically in the past month [5]. These data also consistently show that opioids are the most common prescription drugs used nonmedically.

NMPOU has been linked to numerous adverse health-related consequences, largely due to its depressogenic effects on numerous biological systems, including the central nervous system causing somnolence or even unconsciousness and suppressing respiratory activity, and bowel and lower GI tract (e.g., opioid induced constipation). People who use prescription opioids nonmedically are sometimes also injecting drugs, which is critical from a public health standpoint, because of harms associated with injections such as venous scarring and infectious diseases [12, 13].

It is well documented that people who inject drugs (PWID) often lack stable employment and have inconsistent lines of income [14]. This economic instability means that PWID are often ineligible for government economic subsidies, including employer sponsored health insurance. PWID also experience unstable housing [15, 16] which complicates their ability to achieve a medical home that can provide consistent preventive and acute care. Overall, the highly unstable environment of PWID contributes to poor health and nutrition status, both of which may increase the risk of physical pain related to both chronic and acute conditions [17–20]. There is a longstanding tradition of research on documenting the prevalence of physical pain in general population surveys. Unfortunately, few studies have focused on physical pain in PWID. The limited studies suggest that chronic pain is highly prevalent. In studies by Tsui et al. [21] and Heimer et al. [22], one-third of PWID reported chronic pain. High prevalence of venous insufficiency, causing chronic leg pain, has been shown in PWID [23, 24].

A few large-scale studies have investigated the association among physical pain and NMPOU. Novak et al. [25] showed a positive linear correlation between the level of self-reported pain interference and the likelihood of past year NMPOU in the general North American population. The study further showed that self-reported pain was an independent risk factor for NMPOU, yet its effects were substantially modified by patterns of substance use. A survey of the general population in Sweden showed that more days with poor self-assessed physical health were significantly associated with NMPOU, but not with the nonmedical use of sedatives [26]. Besides these studies, research on NMPOU and its associations with pain is sparse, and studies are conducted mostly in outpatient populations receiving chronic opioid therapy. A meta-analysis by Fishbain et al. [27] showed that a diagnosis of drug abuse, drug dependence or drug addiction was present in 3%-19% of persons with chronic pain. Back pain and multiple pain complaints were factors identifying patients in chronic opioid therapy at high risk for misuse [28]. Other studies of patients with chronic pain showed no association between pain score and NMPOU [29, 30]. A recent longitudinal study by Martel et al. [31] showed that high level of pain was only weakly associated with opioid craving among patients with chronic pain.

A notable gap in the literature is that few studies have investigated the relationship between different dimensions of pain and NMPOU, particularly among high-risk populations who contend with high levels of pain such as PWID. There have been some studies that have explored rather course measures of self-reported pain. For example, Khosla et al. found a positive association between pain and a single measure of any type of nonmedical prescription drug use (NMPD) in American PWID [32]. The authors found that NMPD among PWID was significantly associated with self-reported bodily pain and pain interference with activity, and also with the hazardous use of alcohol, use of illicit substances, and active injection drug use. Misuse of prescription analgesics was the most common type of NMPD (17% reported opiate use in the past 6 months). However, a limitation of this prior work is that pain was assessed with a single item or that pain interference was concerning global functioning. To our knowledge, no studies have examined the relationship between distinct aspects of pain (e.g., location, duration and severity) and NMPOU.

The current paper provides a more refined examination between pain and NMPOU. A primary aim is to, in a sample consisting solely of PWID, describe the prevalence of recent physical pain, pain duration, pain intensity and pain interference. Then, a second aim is to characterize subgroups at differential impairment and functioning related to pain and investigate the association between NMPOU and pain-related factors.

The current study found that both pain and NMPOU were common among PWID, a high-risk population that traditionally lacks access to health care. The findings showing several independent cross-sectional associations between NMPOU and levels of pain and pain interference among PWID are novel and have important clinical implications.

Both recent and long-term pain was common in the study sample, which is similar to the sparse previous research on pain among PWID. Among HIV-positive patients, those who inject drugs have been shown to report more pain than those who do not inject drugs [44, 45]. Also, the prevalence of chronic pain is high among opioid dependent persons in opioid substitution treatment [46]. In one study, 37% reported chronic severe pain [40], and in another 61% reported chronic pain problems [47]. This high pain prevalence is not surprising, considering that homelessness, poverty and several potentially painful conditions such as dental problems [48], abscesses [49–51], other injection-related injuries [52] and chronic wounds [53] are common among PWID.

The primary contribution of this study was that we examined a diverse range of pain-related characteristics. While there was no statistically significant difference regarding NMPOU between subjects reporting no pain in the past 24 h and average pain median or below on the 10-point modified Brief Pain Inventory scale, subjects reporting average pain intensity above the median had more than doubled odds for NMPOU. Conversely, there was no association between NMPOU and pain duration. The association between pain intensity and NMPOU was similar to the results from surveys in the general American population study of non-institutionalized persons aged 18 or older showing a positive linear correlation between level of pain and past year NMPOU [25], but counter to previous research, which have not showed an association between pain and NMPOU in non-PWID cohorts consisting of U.S. veterans [29] and patients with chronic pain [30]. Given that we limited our measures to pain in the past 24 h, it is not surprising that we observed that pain was associated with NMPOU at the event-level over the previous day. Additional studies, perhaps using event-driven sampling like ecological momentary analysis, would be helpful in understanding the linkages between the onset of pain and NMPOU as a means to self-medicate pain.

We also observed that pain interference above median with general activity, walking ability, physical ability, sleep, and enjoyment of life was independently and positively associated with recent NMPOU.

Back pain and lower extremity pain was common in the study sample of PWID. This finding follows a study by Barry et al. [54] showing that chronic pain among persons seeking OST was most commonly located in back or legs. Lower extremity pain is common among PWID and homeless people, due to dermatological problems [55, 56], foot trauma and venous disorders [23, 24]. These pain locations are not notably different from what could be expected in the general population [57–60]. We did not find any significant association between pain location and NMPOU past 24 h, which is consistent with previous studies [29].

While the cross-sectional design of this study allows no interpretation of causality, our findings imply that PWID who use prescription pain relievers non-medically may be attempting to self-medicate or manage pain problems. Self-medication of pain, with heroin or prescription opioids, has been shown to be prevalent in 98% of PWID with moderate or extreme pain [61] and associated with being denied prescription analgesics. However, Heimer et al. [22] showed that four out of five PWID with chronic pain reported NMPOU before debut of their pain. In addition, up to three-quarters of patients with chronic non-cancer pain have been shown to have a lifetime history of substance use disorder [62]. Co-occurrence of pain and nonmedical substance use appears to be a complex matter, and future, longitudinal studies are necessary to assess causal relationships.

Covariates positively associated with NMPOU were younger age, use of street heroin, and unmet healthcare needs. Interestingly, recent use of street heroin was strongly associated with recent NMPOU in this study, while OST was not. Since all subjects in the study were PWID currently using drugs intravenously, this finding allows no interpretation regarding OST as a potential protective factor for avoiding NMPOU. However, future research assessing OST to diminish NMPOU would be of great clinical relevance. Worth noting is also that over half of the population had unmet healthcare needs in the past 6 months. We recommend future studies assessing unmet healthcare needs specifically as a predictor of NMPOU.

This study has several limitations that should be noted. All results were based on self-reports, and no structured clinical diagnosis or drug testing has been performed. We are unsure how the self-reported nature of the data on pain may bias our results, given that pain cannot be objectively measured. We believe that recall bias is kept to a minimum since the pain-related questions and the prescription and street drug questions were mostly about the past 24 h. The possibility of social desirability bias affecting the study participants’ reports of pain and drug use/NMPOU should, however, not be neglected. One additional limitation is that power was low to detect differences in pain as it related to NMPOU. We restricted our time-frame for most of our analyses to the past 24 h. This was done to boost our ability to link the timeframe in which pain could be self-mediated by prescription opioids. Unfortunately, a consequence of this decision was that there were a small number of cases that engaged in NMPOU during that timeframe. If we had expanded the window to the past 30 days, we would have gained statistical power by increasing the number of cases that endorsed NMPOU, but since most of the pain variables in the questionnaire were assessing past 24 h pain, we did not include past 30 days NMPOU data. Since temporality of pain and NMPOU could not assess in this cross-sectional study, reverse causality could not be excluded. It would thus be interesting to conduct longitudinal studies to examine whether individuals began NMPOU because of self-management, and then through habituation became tolerant of opioids. Neither physical comorbidity nor current psychiatric illness was possible to control for, which is an important limitation due to the large body of research data showing overlap between psychiatric morbidity and substance use [26, 29, 42].

The clinical implications of the present study are such that medical care is needed to address the high demand medical health needs of the PWID populations. Recently, several insurance companies in the United States have announced reductions in the patient coverage for opioid use as a means to reduce NMPOU [63, 64]. This complicates the situation for PWID, who already are disenfranchised from medical care and pain relief that could ease their pain and suffering, and there is a concern that prescribing restrictions might limit pain medication acquisition among legitimate pain patients. Previous research on pain management among vulnerable populations has identified inadequate analgesic therapy among 85% of patients with AIDS, and especially among AIDS-patients who were female, low-educated or PWID [65]. Voon et al. [66] showed that two-thirds of 462 PWID had ever been denied prescription analgesics, while 92% reported lifetime disability. Additional research is needed to determine whether or not these policies may have adverse impacts on PWID, including further removal from the main-stream medical system, or whether policies like the Affordable Health Care Act or similar reforms can serve to re-introduce those who have traditionally been excluded from the medical system.

In conclusion, both pain and NMPOU were common among PWID, and pain intensity and pain interference were positively associated with NMPOU in this group. These findings implicate a strong need for improved physical healthcare among PWID. There is also a need for future longitudinal studies assessing the temporal nature of the associations between pain indicators and NMPOU, and evaluations of potential consequences of policies that restrict access to prescription opioids for high-risk populations including PWID.