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Preferences for different features of ENDS products by tobacco product use: a latent class analysis



From a public health perspective, electronic nicotine delivery devices (ENDS) use may be beneficial for some populations (e.g., smokers who fully switch to ENDS) but detrimental for others (e.g., nonsmokers). Understanding the importance placed on different ENDS product features by user groups can guide interventions and regulations.


Participants were US adults who had used ENDS at least once and from a convenience sample drawn from a market research software in 2016. Participants chose between 9 different ENDS product features (harms of use, general effects of use, use as a cessation aid, initial purchase price, monthly cost, nicotine content, flavor availability, device design, and modifiability). A latent class analysis (LCA) identified subgroups of feature preferences and examined differences between groups by socio-demographics and tobacco product use.


Of the 636 participants, 81% were White, the median age was 42, and 65% were current cigarette smokers. The LCA identified a 4-class solution as the most appropriate model: (1) people with high nicotine dependence who preferred ENDS similar to combustible cigarettes, (2) people with moderate tobacco use who were interested in low nicotine ENDS (3) people who use ENDS and combustible tobacco who preferred lower price and flavored ENDS products, and (4) people who used ENDS predominantly, without a strong preference for any of the features presented.


Tobacco use classes were associated with differences in preferences for ENDS features. These findings can inform regulations to reduce ENDS use among specific groups of people who use ENDS products.


Since the introduction of electronic nicotine delivery systems (ENDS) to the U.S. market in 2007 [1], use has risen dramatically [2, 3]. Despite suggestion of harms of ENDS use [4,5,6,7], ENDS use continues to be popular. ENDS are not harmless. Yet for many smokers who are unable or uninterested in quitting cigarettes, ENDS are regarded as a cessation aid or as a potentially less harmful alternative. Different groups of people may use ENDS for different reasons besides cessation such as lower cost compared to other tobacco products, stress reduction, curiosity, consideration for others, and convenience [8,9,10,11]. Other features such as flavors, nicotine content, device design, and functional similarities to cigarettes may also affect the appeal of ENDS to some people who use these products [12, 13]. Studies have also shown that some people who use ENDS stop using these products for several reasons including lack of interest in continuing to experiment with ENDS products, use of ENDS not the same feel as smoking cigarettes, inability to control dose of nicotine, technical concerns, side effects, unpleasant taste and cost [8, 14, 15]. Other less common reasons for discontinuing ENDS use include the persistent craving for tobacco cigarettes even while using ENDS, inability to quit or reduce smoking despite using ENDS while some others stop using ENDS because they quit smoking tobacco cigarettes [8]. One study investigated reason for discontinuation based on reasons for trying with a survey and found that those who started using ENDS for the purposes of quitting or cutting back on tobacco cigarettes were less likely to discontinue use compared with those whose reason for starting was based on curiosity or influence of others [8].

In 2016, the U.S. Food and Drug Administration (FDA) published a final “deeming” regulation that asserted authority to regulate ENDS and additional tobacco products [16]. While FDA cannot change tax levels, states and localities can use taxes and other tools to deter use [17]. Importantly, FDA set a deadline for all products that were not in the market as of February 15, 2007, which includes ENDS products, to submit “premarket tobacco product applications” for all new and existing products they wish to sell [18]. With the FDA’s ongoing consideration of product standards and the potential for regulations that aim to affect ENDS use among specific populations of people, it is important to understand how preferences for different features of ENDS differ by various groups of people who use ENDS. Understanding these differences may guide policymakers as they create regulations for ENDS products.

A method well-suited for classifying individuals into groups based on a set of personal characteristics is mixture modeling. Mixture models are a group of latent variable modeling techniques that allow a researcher to build typologies based on observed variables [19]. One subtype of mixture modeling, latent class analysis (LCA), is used to identify a set of discrete, non-overlapping groups (i.e. latent classes) based on a specific combination of individual characteristics. Individuals are assigned a class value based on the likelihood that their unique characteristics are best captured by their assigned class [20, 21].

The current study applies LCA to data collected in 2016 as part of a discrete choice experiment (DCE) of ENDS products using a convenience sample of people who use ENDS in the U.S. Data on stated preferences for features of ENDS products were used to construct the LCA classes, and sociodemographic factors, ENDS and other tobacco product use were used to further characterize class membership. This approach allowed us to identify product features especially attractive to different groups of people who use ENDS.


Study design

In a cognitively tested DCE embedded in a survey, participants indicated the importance of different ENDS features for their use [11, 12]. The survey was administered in August 2016 using Sawtooth software (Provo, Utah). Sawtooth is an online software platform to create and field discrete choice questions as well as assist with analysis of choice experiments. (Sawtooth) The experiment was designed from a best-worst scaling, case 2 DCE [22] The experiment was conducted with a total of 19 hypothetical products, with each product made up of 5 different features chosen from a total of 9 possible features. Specifically, the 9 features were: harms of use, general effects of use, use as a cessation aid, initial purchase price, monthly cost, nicotine content, flavor availability, device design, and modifiability [12]. Each respondent was presented with one product at a time, and for each product, was asked the following question “Please imagine this is a new e-cigarette that has just become available for purchase. When you look at the 5 features of the e-cigarette, which feature makes you most want to use the e-cigarette and which feature makes you least want to use the e-cigarette?” Each feature had 3 to 4 different levels relating to that feature. For example, the feature “one time purchase cost,” with 4 levels: $5, $55, $115, or $175 (Table 1).

Table 1 List of discrete choice experiment features and levels

The development of the list of features and levels and further details of the study design can be found elsewhere [11, 12]. The Institutional Review Board of UNC Chapel Hill School of Medicine approved this study.


Participants were recruited from the survey panel of Research Now, an online research survey company. To be eligible for the study, participants had to be 18 years or older, reside in the United States, be able to speak and read English, have access to the internet, and report having used ENDS at least once in their lifetime.

Survey measures

The survey included questions about participant sociodemographic factors including gender, age, race/ethnicity, education, household income, and general health. The survey also asked about tobacco product use including past and current ENDS use, the use of flavored ENDS, anticipated future ENDS use, use of other tobacco products, current cigarette smoking (cigarettes per day), age first started smoking, dual use of ENDS and combustible products, nicotine dependence, and past attempts to quit [23, 24].


The Choice Based Conjoint Hierarchical Bayesian module in Sawtooth Software typically uses a mixed effects multivariate, multinomial logit modeling approach to generate population mean “utilities,” which in this specific case represents the various ENDS features and their levels. In the current analysis we also used a mixed modeling approach; however, we used LCA to identify groups or “classes” of individuals based on their choices of the hypothetical ENDS products. Such an approach allowed us to explore whether different groups value certain constellations of ENDS features more than others. We iteratively tested 2 through 8 class LCA models and, using a combination of relative model fit statistics (e.g., Bayesian Information Criterion; BIC) and theory, identified the optimal class solution. We then compared the classes on key tobacco use and sociodemographic variables. Tobacco use classification was based on the heaviness of smoking index score, determined by the number of tobacco cigarettes smoked in a day and the time to first cigarette use after wake [23].


Participant characteristics

A total of 636 met the inclusion criteria, and thus comprise the analytic sample for this study. The mean age was 42 years (SD ± 19) and 49% were female. Participants were majority White (81%) and 13.8% identified as Latino/Hispanic. Approximately one third of the sample had a college degree and 60% reported a household income under $60,000 per year (Table 2). Most participants (92%) reported that they had tried cigarette smoking and 65% were current smokers. In the sample, 63% reported ENDS use in the past 30 days. Of those who previously tried cigarettes (n = 588), 67% first started smoking before age 18 and 40% had used both ENDS and a combustible tobacco product in the past 30 days (dual use). Of the current cigarette smokers (n = 415), 59% reported smoking within 30 min of waking and 46% tried to quit tobacco cigarettes within the past 12 months (Table 3).

Table 2 Sample demographic characteristics – 4 class solution
Table 3 Tobacco use by 4 class membership

LCA findings

Relative model fit for the -2LL, Akaike Information Criterion (AIC), and BIC substantially improved between the 2 class (−2LL = − 30,254.06, AIC = 60,634.13, and BIC = 61,143.98) and 3 class (−2LL = − 29,578.59, AIC = 59,347.21, and BIC = 60,116.02) models [BIC χ2 difference (1) =1097.26, p < .001]. Model fit similarly improved between the 3 and 4 class (−2LL = 58,612.22, AIC = 58,612.22, and BIC = 59,640.00) models [BIC χ2 difference (1) =476.02 p < .001]. However, improvements in model became increasingly attenuated in models with a higher number of classes. Based on these observations, as well as on the tobacco use and sociodemographic differences between the 4 and 5 factor model classes, we ultimately identified the 4-class model as the best fitting model (Fig. 1. 4 Class Solution). Figure 1a, b and c represents the 4 classes for the features based on their overall themes with Fig. 1a representing features related to cost of use, Fig. 1b representing features under health effects and Fig. 1c for features related to the device. Although an individual’s true class membership cannot be definitively known, it is possible to compute probability of class membership using posterior probabilities, which are derived from the latent class measurement model [25]. The average maximum membership probability for the 4-class solution was 0.95548, which indicates minimal classification error.

Fig. 1
figure 1

4 class solution for all features. a: 4 class solution for features related to cost of use. b: 4 class solution for features related to health effects. c: 4 class solution for features related to the device. Class 1: People with high nicotine dependence. Class 2: People with moderate tobacco use. Class 3: People who use ENDS and combustible tobacco. Class 4: People who use ENDS predominantly. On each figure, the horizontal axis has the different levels of represented features while the vertical axis represents preferences. For each class, a higher number on the Y axis indicates a higher preference for the corresponding ENDS feature level on the X-axis

Class characterizations

The four identified classes were labeled based on their tobacco use characteristics. Tobacco cessation was important to 3 of the 4 classes and did not help distinguish the classes. These are distinguished as follows:

CLASS 1 – People with high nicotine dependence (n = 169, 27%) preferred ENDS products with device design similar to tobacco cigarettes. This class had 60% male, majority White (92%) and non-Latino (94%) compared to other classes. These individuals also had low rates of ENDS use, high cigarette use, had high dependence, and had the lowest rates of successful quit attempts compared to other classes.

CLASS 2 - People with moderate tobacco use (n = 159, 25%) were more interested in ENDS with low nicotine levels but less interested in ENDS products design. Like Class 1, this class skewed male (60%), but was more racially diverse (77%, White; 9% African American; 5% Asian; 8% other racial group). This group had a low rate of ENDS use and participants were less likely to anticipate ENDS use in the future. Participants in this group had lower levels of nicotine dependence compared with participants in groups 1 and 3 and had higher rates of success with quitting.

CLASS 3 - People who use ENDS and combustible tobacco (n = 147, 23%) were the most price conscious of all classes and more interested in flavors compared to all other classes. This class was as interested in ENDS products with design similar to cigarettes as Class 1 but comparatively less concerned about the relative health harms and negative effects of ENDS on their appearance. Class 3 had a more even distribution of gender (48% male) but was similar to Class 1 in terms of race/ethnicity. Class 3 also had the high ENDS use, high cigarette use, high dependence, and the highest rates of dual ENDS and combustible use among all classes.

CLASS 4 – People who use ENDS predominantly (n = 161, 25%) were largely insensitive to ENDS product features. There were modest effects noted for price, similarity to cigarettes, health harms, effects on appearance, and flavor, but these were substantially muted compared to the other classes. Class 4 was the most female (63%), most diverse (71% White, 26% Latino/Hispanic, 14% Asian, 7% other racial group), and the youngest compared to all other classes. ENDS use was the highest in this class (75% past-30-day use) but other tobacco product use for this group was generally lower. Those in class 4 had a moderate level of nicotine dependence compared to other classes.


This is the first research to identify preferences for different features of ENDS products by tobacco product use and sociodemographic factors. ENDS features that increased appeal were device design similar to cigarettes, low nicotine content, lower price, improved flavor. Class 1 members tend to be people with heavy cigarette use, who have had more trouble quitting and see appeal in ENDS products that are similar to cigarettes. Class 2 members tend to use cigarettes in more moderate amounts with lower levels of dependence and prefer products with lower nicotine level. Class 3 group members had the highest levels of dual ENDS and combustible tobacco use but were more price conscious, more interested in flavors, and less concerned about health effects. Class 4 members had high ENDS use but lower tobacco use and were largely insensitive to product features.

Class 1 group members showed preference for ENDS products that are similar to tobacco cigarettes. Research shows that there are certain sensorimotor features of ENDS products that increase their appeal to those who use cigarettes including airway stimulation, movement of hand-to-mouth and aerosol exhalation [26], making it easy to switch between the two. Some studies show increase in smoking cessation rates among smokers after starting using ENDS, suggesting that ENDS may be used as nicotine replacement therapy [27,28,29]. While the preferred goal is complete tobacco cessation, ENDS may be a useful harm-reduction strategy for those who cannot or will not quit nicotine. To support smokers who may benefit from ENDS, regulators may choose to encourage products that most closely mimic cigarettes [30].

Class 2 members preferred ENDS products with less nicotine and were less concerned about device design. Studies show that the nicotine content of ENDS can vary widely (from 0 to 35 mg/ml) [31, 32] and that nicotine content labels are not always accurate [5, 33]. Low levels of nicotine in ENDS products has been associated with trying ENDS products because it decreases the perception of harm [34]. Some people who use ENDS who try to quit smoking appreciate the ability to choose their nicotine levels and taper down their nicotine [35, 36]. However, people who use ENDS may compensate by using the e-cigarettes more often or inhaling more deeply. Another problem is that even when cartridges of ENDS products have the same level of nicotine, they may deliver different levels to people at different times, further leading to inconsistencies with the levels of nicotine that people think they are receiving with each use [33, 37]. It remains to be seen whether tapering nicotine levels in ENDS is a useful approach for reducing nicotine dependence, or whether it merely facilitates ENDS compensation or dual use of ENDS and combustible tobacco [38]. If low levels of nicotine support cessation of combustible cigarettes, then regulators will want to encourage the continued availability of different nicotine levels, ensure consistent labelling of nicotine content, and enact quality control to ensure that the nicotine level on the container matches the actual nicotine content.

Class 3 was made up of people with high levels of the use of both ENDS and tobacco products and a high level of nicotine dependence. This class was the most price conscious of the 4 classes. Pricing of tobacco products is a one of the most powerful tools in affecting tobacco product use. One study showed that an increase in price by 10% results in a 12% drop in sales of disposable ENDS and 18% decrease in sales for reusable ENDS [39]. States have the authority to regulate ENDS products and can set the minimum price by raising or lowering taxes on these products [40]. Although the FDA is unable tax ENDS products, regulations that increase cost would affect sale prices [41]. Studies also show cross-product price elasticity i.e. the relative price of cigarettes and e-cigarettes can affect the use of each [42]. Hence, if states lower taxes on ENDS, this will reduce the cost and may shift some people who use both products from the more harmful combustible tobacco products to the lower risk ENDS products.

Members of class 3 were also interested in flavors. Flavors strengthen the appeal of ENDS products and have also been associated with rewarding and reinforcing the value of ENDS products, hence increasing the desire to use [43,44,45,46]. Similar to our findings, research shows that people who use both ENDS and tobacco cigarettes have a higher likelihood of using flavored ENDS products compared with those who use a single product [30, 47]. In one study, people who use both products self-reported intention to reduce or quit ENDS use and increase tobacco cigarette use if restrictions were placed on ENDS flavors [48]. The challenge for regulators is to limit use while not overly deterring smokers from using ENDS for cessation or harm-reduction [49].

Our final class [4], comprised of people who use ENDS predominantly, had no strong preference for the ENDS features we offered. While ENDS use is very high in this class, these people may be less attached to ENDS than other classes. This class was made up of a more diverse and younger group (mean age 33 versus 42–46 for the other groups). This group may be more sensitive to attributes that are harder to measure, which may represent a unique challenge for policy makers. Alternatively, these participants may be willing to pay any price for ENDS and their use may not be affected by any particular ENDS feature. Therefore, any FDA regulatory action on ENDS may not affect their use of these products.


This study was used on an online convenience sample of U.S. participants drawn from a national survey panel and may not be representative of all those who use ENDS. However, tobacco control studies using convenience samples have tended to replicate the same patterns of statistical significance as nationally representative survey (albeit with different point estimates) [50]. Second, the preferences collected in the LCA are self-report and subject to social desirability and other biases. This data was collected in 2016 and the marketplace for ENDS has changed significantly with new products and modification of previously existing products. Some currently available ENDS products may have other features not present in this study, and choice experiments are limited by the number of attributes used, hence study findings may not be generalizable. In addition, preferences for hypothetical products may also not fully match what happens in real life when presented with a new product—marketing, peer use, accessibility, and other factors likely play a role. The LCA model assumes that patterns observed are typical of underlying subpopulations, which may not always be exact.


FDA has a wide array of regulatory powers over ENDS, and states and localities have additional policy tools and approaches at their disposal. These regulatory decisions, including those regulating the characteristics of ENDS, likely affect who chooses to use ENDS and for what purpose. The present study provides a starting point about what characteristics matter and to whom. Knowing the preferences of different groups of people who use ENDS can allow policymakers to craft regulations that reduce ENDS among people who should not use them and allow ENDS use for people who need them.

Availability of data and materials

The datasets used and/or analyzed for this study are available from the corresponding author on reasonable request.


  1. Historical timeline of vaping and electronic cigarettes. Accessed 9 Nov 2020.

  2. Villarroel MA, Cha AE, Vahratian A. Electronic cigarette use among U.S. Adults, 2018. NCHS Data Brief. 2020;(365):1–8.

  3. Cullen KA, Ambrose BK, Gentzke AS, Apelberg BJ, Jamal A, King BA. Notes from the field: use of electronic cigarettes and any tobacco product among middle and high school students - United States, 2011-2018. MMWR Morb Mortal Wkly Rep. 2018;67(45):1276–7.

    Article  Google Scholar 

  4. Kennedy CD, van Schalkwyk MCI, McKee M, Pisinger C. The cardiovascular effects of electronic cigarettes: a systematic review of experimental studies. Prev Med. 2019;127:105770.

    Article  Google Scholar 

  5. Cheng T. Chemical evaluation of electronic cigarettes. Tob Control. 2014;23 Suppl 2:ii11-7.

    PubMed  Google Scholar 

  6. Hua M, Talbot P. Potential health effects of electronic cigarettes: a systematic review of case reports. Prev Med Rep. 2016;4:169–78.

    Article  Google Scholar 

  7. Flach S, Maniam P, Manickavasagam J. E-cigarettes and head and neck cancers: a systematic review of the current literature. Clin Otolaryngol. 2019;44(5):749–56.

    Article  Google Scholar 

  8. Pepper JK, Ribisl KM, Emery SL, Brewer NT. Reasons for starting and stopping electronic cigarette use. Int J Environ Res Public Health. 2014;11(10):10345–61.

    Article  Google Scholar 

  9. Rutten LJF, Blake KD, Agunwamba AA, Grana RA, Wilson PM, Ebbert JO, et al. Use of E-cigarettes among current smokers: associations among reasons for use, quit intentions, and current tobacco use. Nicotine Tob Res. 2015;17(10):1228–34.

    Article  Google Scholar 

  10. Patel D, Davis KC, Cox S, Bradfield B, King BA, Shafer P, et al. Reasons for current E-cigarette use among U.S. adults. Prev Med. 2016;93:14–20.

    Article  Google Scholar 

  11. Kistler CE, Crutchfield TM, Sutfin EL, Ranney LM, Berman ML, Zarkin GA, Goldstein AO. Consumers’ preferences for electronic nicotine delivery system product features: A structured content analysis. Int J Environ Res Public Health. 2017;14(6):613.

  12. Kistler CE, Ranney LM, Sutfin EL, Chrzan K, Wretman CJ, Enyioha C, et al. Product attributes important to US adult consumers’ use of electronic nicotine delivery systems: a discrete choice experiment. BMJ Open. 2019;9(8):e027247.

    Article  Google Scholar 

  13. Zare S, Nemati M, Zheng Y. A systematic review of consumer preference for e-cigarette attributes: flavor, nicotine strength, and type. PLoS One. 2018;13(3):e0194145.

    Article  Google Scholar 

  14. Kralikova EVA, Kubatova S, Truneckova K, Kmetova A, Hajek P. The electronic cigarette: what proportion of smokers have tried it and how many use it regularly? Addiction. 2012;107(8):1528–9.

    Article  Google Scholar 

  15. Etter J-F. Electronic cigarettes: a survey of users. BMC Public Health. 2010;10:231.

    Article  Google Scholar 

  16. Food and Drug Administration, HHS. Deeming Tobacco Products to Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final rule. Fed Regist. 2016;81(90):28973–9106.

  17. The Federal Response to the epidemic of E-cigarette use, especially among children, and the Food and Drug Administration’s compliance policy. [internet]. He Federal Response to the epidemic of E-cigarette use, especially among children, and the Food and Drug Administration’s compliance Policy. 2019 [cited 2022 Feb 14]. Available from:

  18. Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems - Guidance for Industry [Internet]. Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems (ENDS). 2019 [cited 2022 Feb 14]. Available from:

  19. Oberski D. Mixture models: latent profile and latent class analysis. In: Robertson J, Kaptein M, editors. Modern statistical methods for HCI. Cham: Springer International Publishing; 2016. p. 275–87.

    Chapter  Google Scholar 

  20. Lanza ST, Rhoades BL. Latent class analysis: an alternative perspective on subgroup analysis in prevention and treatment. Prev Sci. 2013;14(2):157–68.

    Article  Google Scholar 

  21. Deiches JF, Baker TB, Lanza S, Piper ME. Early lapses in a cessation attempt: lapse contexts, cessation success, and predictors of early lapse. Nicotine Tob Res. 2013;15(11):1883–91.

    Article  Google Scholar 

  22. Flynn TN, Louviere JJ, Peters TJ, Coast J. Estimating preferences for a dermatology consultation using best-worst scaling: comparison of various methods of analysis. BMC Med Res Methodol. 2008;8:76.

    Article  Google Scholar 

  23. Heatherton TF, Kozlowski LT, Frecker RC, Rickert W, Robinson J. Measuring the heaviness of smoking: using self-reported time to the first cigarette of the day and number of cigarettes smoked per day. Br J Addict. 1989;84(7):791–9.

    CAS  Article  Google Scholar 

  24. Centers for Disease Control and Prevention. National Adult Tobacco Survey Questionnaire, 2013–2014. Accessed 2 Feb 2021.

  25. Bray BC, Lanza ST, Tan X. Eliminating Bias in classify-analyze approaches for latent class analysis. Struct Equ Modeling. 2015;22(1):1–11.

    Article  Google Scholar 

  26. United States Public Health Service Office of the Surgeon General; National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. Smoking Cessation: A Report of the Surgeon General [Internet]. Washington (DC): US Department of Health and Human Services; 2020.

  27. Polosa R, Caponnetto P, Maglia M, Morjaria JB, Russo C. Success rates with nicotine personal vaporizers: a prospective 6-month pilot study of smokers not intending to quit. BMC Public Health. 2014;14:1159.

    Article  Google Scholar 

  28. Etter J-F, Bullen C. A longitudinal study of electronic cigarette users. Addict Behav. 2014;39(2):491–4.

    Article  Google Scholar 

  29. Bullen C, Howe C, Laugesen M, McRobbie H, Parag V, Williman J, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013;382(9905):1629–37.

    Article  Google Scholar 

  30. Harrell MB, Weaver SR, Loukas A, Creamer M, Marti CN, Jackson CD, et al. Flavored e-cigarette use: characterizing youth, young adult, and adult users. Prev Med Rep. 2017;5:33–40.

    CAS  Article  Google Scholar 

  31. Schroeder MJ, Hoffman AC. Electronic cigarettes and nicotine clinical pharmacology. Tob Control. 2014;23 Suppl 2:ii30-5.

    PubMed  Google Scholar 

  32. Sidani JE, Colditz JB, Barrett EL, Shensa A, Chu K-H, James AE, et al. I wake up and hit the JUUL: analyzing twitter for JUUL nicotine effects and dependence. Drug Alcohol Depend. 2019;204:107500.

    Article  Google Scholar 

  33. Goniewicz ML, Kuma T, Gawron M, Knysak J, Kosmider L. Nicotine levels in electronic cigarettes. Nicotine Tob Res. 2013;15(1):158–66.

    CAS  Article  Google Scholar 

  34. Czoli CD, Goniewicz M, Islam T, Kotnowski K, Hammond D. Consumer preferences for electronic cigarettes: results from a discrete choice experiment. Tob Control. 2016;25(e1):e30–6.

    Article  Google Scholar 

  35. Polosa R, Caponnetto P, Cibella F, Le-Houezec J. Quit and smoking reduction rates in vape shop consumers: a prospective 12-month survey. Int J Environ Res Public Health. 2015;12(4):3428–38.

    CAS  Article  Google Scholar 

  36. Etter J-F. A longitudinal study of cotinine in long-term daily users of e-cigarettes. Drug Alcohol Depend. 2016;160:218–21.

    CAS  Article  Google Scholar 

  37. Cameron JM, Howell DN, White JR, Andrenyak DM, Layton ME, Roll JM. Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions: table 1. Tob Control. 2014;23(1):77–8.

    Article  Google Scholar 

  38. Sahr M, Kelsh SE, Blower N. Pharmacist assisted vape taper and behavioral support for cessation of electronic nicotine delivery system use. Clin Case Rep. 2020;8(1):100–3.

    Article  Google Scholar 

  39. Huang J, Tauras J, Chaloupka FJ. The impact of price and tobacco control policies on the demand for electronic nicotine delivery systems. Tob Control. 2014;23 Suppl 3:iii41-7.

    PubMed  Google Scholar 

  40. Feldman EA. Layers of law: the case of e-cigarettes. FIU L Rev. 2014;10:111.

  41. Buckell J, Sindelar JL. The impact of flavors, health risks, secondhand smoke and prices on young adults’ cigarette and e-cigarette choices: a discrete choice experiment. Addiction. 2019;114(8):1427–35.

    Article  Google Scholar 

  42. Huang J, Gwarnicki C, Xu X, Caraballo RS, Wada R, Chaloupka FJ. A comprehensive examination of own- and cross-price elasticities of tobacco and nicotine replacement products in the U.S. Prev Med. 2018;117:107–14.

    Article  Google Scholar 

  43. Huang L-L, Baker HM, Meernik C, Ranney LM, Richardson A, Goldstein AO. Impact of non-menthol flavours in tobacco products on perceptions and use among youth, young adults and adults: a systematic review. Tob Control. 2017;26(6):709–19.

    Article  Google Scholar 

  44. Kowitt SD, Meernik C, Baker HM, Osman A, Huang LL, Goldstein AO. Perceptions and experiences with flavored non-menthol tobacco products: A systematic review of qualitative studies. Int J Environ Res Public Health. 2017;14(4):338.

  45. Audrain-McGovern J, Strasser AA, Wileyto EP. The impact of flavoring on the rewarding and reinforcing value of e-cigarettes with nicotine among young adult smokers. Drug Alcohol Depend. 2016;166:263–7.

    CAS  Article  Google Scholar 

  46. Meernik C, Baker HM, Kowitt SD, Ranney LM, Goldstein AO. Impact of non-menthol flavours in e-cigarettes on perceptions and use: an updated systematic review. BMJ Open. 2019;9(10):e031598.

    Article  Google Scholar 

  47. Smith DM, Bansal-Travers M, Huang J, Barker D, Hyland AJ, Chaloupka F. Association between use of flavoured tobacco products and quit behaviours: findings from a cross-sectional survey of US adult tobacco users. Tob Control. 2016;25(Suppl 2):ii73–80.

    Article  Google Scholar 

  48. Pacek LR, Rass O, Sweitzer MM, Oliver JA, McClernon FJ. Young adult dual combusted cigarette and e-cigarette users’ anticipated responses to hypothetical e-cigarette market restrictions. Subst Use Misuse. 2019;54(12):2033–42.

    Article  Google Scholar 

  49. Friedman AS, Xu S. Associations of flavored E-cigarette uptake with subsequent smoking initiation and cessation. JAMA Netw Open. 2020;3(6):e203826.

    Article  Google Scholar 

  50. Jeong M, Zhang D, Morgan JC, Ross JC, Osman A, Boynton MH, et al. Similarities and differences in tobacco control research findings from convenience and probability samples. Ann Behav Med. 2019;53(5):476–85.

    Article  Google Scholar 

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This work was supported by the University of North Carolina at Chapel Hill University Cancer Research Fund at the Lineberger Comprehensive Cancer Center, which is supported through the National Cancer Institute (P30 CA16086) and The CHAI Core (The UNC Connected Health for Applications and Interventions), which is supported by the National Institutes of Health (DK056350). Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number K01CA253234 (MJB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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CE and CK developed the research aims. CE, CK, MB and LR contributed to refining the research question and concept. MB conducted the analysis. CE drafted the manuscript. MB, LR, MJB, AG and CK contributed to the editing and revision the manuscript. All authors read and approved the final manuscript.

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Correspondence to Chineme Enyioha.

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This study was approved by the University of North Carolina Institutional Review Board.

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Enyioha, C., Boynton, M.H., Ranney, L.M. et al. Preferences for different features of ENDS products by tobacco product use: a latent class analysis. Subst Abuse Treat Prev Policy 17, 18 (2022).

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  • ENDS
  • Tobacco products
  • Regulations
  • Cessation