- Open Access
Sexual and reproductive health correlates of polysubstance use among female adolescents who sell sex in the southwest of China
Substance Abuse Treatment, Prevention, and Policy volume 15, Article number: 59 (2020)
Substance use and adverse sexual and reproductive health (SRH) outcomes continue to be significant threats to female adolescents’ health and wellbeing, particularly to these marginalized subpopulations. Our research aimed to tackle knowledge gaps regarding the prevalence of concurrent substance use including alcohol, tobacco, illicit drug among Chinese adolescent female sex workers (AFSWs), while to assess the correlates between substance use and SRH risks; the needs for comprehensive SRH services were also examined in this study.
A cross-sectional study enrolled 310 AFSWs aged 15–19 years by using cluster sampling method in Kunming, China. Descriptive analysis was employed to characterize the participants who were regular-alcohol users, regular-tobacco users, illicit drug users and polysubstance users. Multivariable logistic regression analysis was performed to detect the SRH correlates of regular-alcohol use, regular-tobacco use, illicit drugs and polysubstance use respectively.
There is a high prevalence of regular-alcohol drinking (83%, 257/310) among AFSWs, with 44% (136/310) smoking cigarettes regularly and 9% using illicit drug (27/310) in the past year. In multivariate analysis, AFSWs who had middle and high school education, had higher monthly income, experienced of sexual and gender based violence (SGBV) and prior abortion, and regular-tobacco smoking were associated with increased odds of regular-alcohol drinking; engaging in unprotected sex while drunk, having STIs symptoms and using illicit drugs were significantly associated with regular-tobacco smoking; while AFSWs who had an illicit drug using- intimate partner, experienced forced sexual initiation, accessed unsafe medical providers for STIs treatment were associate with increased odds of illicit drug use. Moreover, 35% (105/298) AFSWs sought unsafe medical care for STIs treatment, or no treatment at all, among them, majority were using polysubstance (87%; 91/105).
Our findings reveal combined threats of substance use to AFSWs’ SRH and wellbeing in China, this study emphasises that the coordinated efforts are needed to integrate SRH promotion and harm reduction service across sectors, and not only fragmented measures. An effective response should include an agreed framework, indicators and targets supported by political will, solid leadership and policy reform to deal with AFSWs’ overlapping vulnerabilities in a systematic way.
Adolescence is a critical stage of life characterised by rapid biological, emotional and social development. There are about 1.2 billion adolescents aged 10–19 years in the world today; 13% (154,222,000) of adolescent women aged 15–19 years live in China . Now themes regarding adolescents’ sexual and reproductive health (SRH) and rights, substance use prevention and treatment are higher on the global development agenda than ever before, and are currently featured on the the 2030 Agenda of Sustainable Development Goals (Target 3.a, Target 3.5, Target 3.7, Target 4.5 and Target 5.6) because of the far-reaching implications for their health and for social and economic development . A critical new priority at the heart of the updated Global Strategy for Women’s Children’s and Adolescents’ Health (2016–2030) is the focus on adolescents. This Global Strategy also brings a broader concept of adolescent SRH by including HIV and other sexually transmitted infectious (STIs), non-communicable diseases (NCDs), and mental and substance use disorders .
Substance use among adolescents can lead to increased risk of STIs including HIV, vehicular fatalities, juvenile delinquency, and other NCDs problems associated with physical and mental health . Global Burden of Disease Study brought to light, in 2017, smoking and alcohol use disorders were the third and tenth leading contributor to the number of deaths and percentage of age-standardized disability-adjusted life-years (DALYs) in China . Across the 10–24 year age group, alcohol misuse was the risk factor contributing to the highest proportion (7%) of DALYs, and alcohol misuse and drug use disorders were the risk factors for DALYs for Chinese young people aged 20–24 years; furthermore, unsafe sex was the most significant risk factor for DALYs lost for adolescents aged 15–19 years . Meanwhile, adverse SRH consequences disproportionately affect female adolescents who use alcohol and tobacco , for example, maternal smoking during pregnancy is a particular risk factor for poor fetal growth as well as later-life illness in offspring ; alcohol use during puberty adversely affects the maturation of the reproductive system while greater use of alcohol in pregnancy has prominent intergenerational harms in the form of fetal alcohol syndrome .
Although most in need, a scarcity of data limits of substance use and associated SRH risks concerning marginalised or vulnerable adolescents are a major challenge . Across developing countries, there are underreporting gaps in data and research related to the adolescents’ substance use behaviours and SRH outcomes, that situation is more specifically in China . Moreover, the Guttmacher Institute report on adolescent women’s need for and use SRH health services in 70 developing countries showed that only nine Asian countries but China had data available . In China, all forms of sex work are illegal and highly stigmatised; sex workers are often treated as quasi-criminals and can receive administrative penalties of 15-day detention or fines . Adolescents who both sell sex and use drugs face heavier penalties. Aside from political tension and criminalisation, the social norms and cultural taboos usually bring more ethical challenges into SRH promotion actions and research in marginalized adolescents , consequently adolescent female who sell sex or/and use drugs as a class remains hidden and ignored in China [11, 12]. The lack of basic knowledge hinders effective responses for the adolescent female sex workers (AFSWs)’ SRH and wellbeing. To make these marginalized adolescents visible in policy design and programme initiatives, specific investigation is needed to record the patterns substance use including alcohol, illicit drugs and tobacco, to explore the relations between substance use and the broad SRH risks including HIV/STIs, unmet need for modern contraception, abortion, sexual and gender-based violence (SGBV), SRH care seeking behaviours and specific service needs.
In 1977, the American pathologist and psychiatrist George Engel first conceptualized and introduced the biopsychosocial model that combines biological, psychological and social factors to understand health and illness . This approach is rooted in ‘general systems theory’, which states that a system is characterised by the interactions of its components. As an applied multidisciplinary science, biopsychosocial model is well applied by specialist societies in obstetrics and gynaecology areas ; meanwhile a variety of studies used the biopsychosocial model for examining the roles of environment and personal values (i.e., psychosocial factors) in the onset of adolescent risk-taking behaviour, for example, the initiation of substance use . Now the Global Strategy for Women’s Children’s and Adolescents’ Health calls for a multisector approach to improve the health and wellbeing of adolescents. Thus, the biopsychosocial model provides a valuable basis for our research to explore how social-economic, social-environmental, substance use and broader SRH factors interact in AFSWs’ underlying vulnerabilities, and ultimately, determine key areas for collaborative intervention action.
Our research aimed to tackle knowledge gaps regarding the prevalence of concurrent alcohol, tobacco, illicit drug and polysubstance use among Chinese AFSWs, as well as to assess the correlates between these substance use and SRH risks respectively; the needs for comprehensive SRH services were also examined in this study.
Study setting and population
Yunnan Province on China’s southwestern border is close to the ‘Golden Triangle’, a major international business and drug trafficking route. This province has a long and evolving history of drug trade as a notorious centre in China, seizures made by Yunnan along the ‘Golden Triangle’ route accounted for 83% of national quantities of heroin, ketamine and amphetamines seized in 2019 . The health consequences documented include a relatively high HIV-1 prevalence and other STIs in China ; between 2010 and 2015, more than 10,000 new HIV/AIDS diagnoses occur among women aged 15–49 years . Meanwhile Yunnan is also the largest grower of tobacco leaf and has cigarette industry in China, roughly 70% of Yunnan Province’s annual tax revenue is collected from the tobacco industry . This study was conducted in Kunming city, which is the largest economic centre and the capital city of Yunnan Province, has an estimated population of 7.2 million. It is estimated that about 10,200 FSWs were active in Kunming (approximately 0.33% of Kunming’s female population) in 2013, with about 7900 (77%) concentrated in urban areas , the proportion estimates of AFSWs range from 15 to 25% . Due to the notable paucity of studies and official data reporting HIV/STIs prevalence and population estimation of FSWs after 2015 in China , as well as data scarcity on the changing patterns of substance use among AFSWs, in June 2020, we conducted in-depth interviews among 5 key informants from two non-governmental organizations supporting FSWs and the Kunming Chinese Centre of Disease Control. Interviewees reported that the number of less-educated young and out-of-school adolescent women involved in sex trade was increased than 2013. In the past decade, annually millions of people from countryside move to big cities across China driven by the government’s urbanization plan. Overall, the number of rural-to-urban young women involved in providing sexual services is often greater than their urban residents counterparts. Potential motivation is link to economic hardship or the lure of fast and easy earnings, needs of sharing rent or building relationship, and limited employment opportunities for less-educated female migrants. However, sex work no longer remains a full-time job for many AFSWs, they tend to see the commercial sex as a temporary or occasional arrangement without perceiving themselves to be sex workers. While the types of worksites for soliciting clients are shifting due to the popularization of smartphone and social media platforms. Thus the observed number of AFSWs who are working at traditional entertainment establishments (e.g., karaoke, night club, dancing hall, disco, bar) or personal service sectors (e.g., hair washing room, hair salon, massage parlour, sauna, restaurant, hotel) has declined over time. On the other hand, based on interviewees’ routine work contact, the number of cases of HIV/AIDs or other STIs (such as syphilis) among these adolescent women involved in all forms of commercial sex has grown since 2018, suggesting the SRH risks were more continually to occur.
Our study was designed to enrol consenting females aged 15–19 years who self-reported to have received money or gifts in exchange for sex from one or more paying clients in the past 6 months, and were living in urban sites during the period of study. This study referred enrolled adolescent females engaged in commercial sex as AFSWs.
This was a cross-sectional study using the Chinese version of semi-structured questionnaires which adopted questions regarding knowledge of family planning, knowledge of HIV/STIs, sexual relationship and behaviour from the ‘WHO questionnaire for young people’  and the ‘Indonesia Demographic and Health Survey Questionnaire for Young Adult Reproductive Health’ ; some questions regarding SGBV and relationship control were adopted from a cohort study of FSWs in Kenya . All three original instruments had been tested for reliability and validity. Two pilot tests using the draft questionnaire were conducted among key informants (leaders of FSWs’ support organizations/frontline clinic doctors/senior peer educators/outreach workers) and 14 AFSWs.
The study was implemented in collaboration with Kunming-based, FSW-led, grassroots organizations and the district level Chinese Centres of Disease Control. A total of 101 locations in four urban districts of Kunming were identified as places where young FSWs worked frequently. A stratified random sampling was planned, however the ongoing nationwide police crackdown on the sex industry made it impossible; instead, a one-stage cluster sampling method was employed to recruit study participants between September 2012 and February 2013. The initial stage of sampling involved 27 clusters (locations), which were randomly selected from the 101 identified locations, proportionate to the total number of locations in each district area. Potentially eligible women were recruited from the 27 clusters.
Six health workers (clinical doctors/nurses selected from district level health facilities) and six peer educators (FSWs from local grassroots organizations) were trained as interviewers about the ethical issues, study purpose, survey procedures and questionnaire administration. Using a semi-structured questionnaire, face-to-face interviews were conducted at 27 locations, and each interview took 40–50 min to complete.
For the purposes of this analysis, we focused on regular-alcohol drinking, regular-tobacco smoking, illicit drug and polysubstance use as four dependent variables; while based on the biopsychosocial model framework, independent variables were selected and grouped into the following five dimensions, namely: socio-demographic characteristics, sex work, sexual behaviours, sexual health, and concurrent substance use.
Since there is some scientific and legal ambiguity about the distinctions between substance ‘misuse’ and ‘abuse’, in this study, the neutral term ‘substance use’ was used. Substance types and use patterns were measured including alcohol, tobacco, illicit drugs, and polysubstance in the past 12-month period before the survey date.
Illicit drug use was defined as the self-reported use any sort of heroin, methamphetamine pill, crystalline methamphetamine, marijuana, ketamine and ecstasy.
Alcohol use was assessed by the self-reported frequencies of alcohol drinking, and was dichotomised as abstainer or occasional-alcohol drinking (once per week or less) versus regular-alcohol drinking (daily or more than twice a week).
Tobacco use was defined as self-reported frequencies of cigarette smoking, and dichotomised as abstain or occasional-tobacco smoking (less than 1–2 times monthly), and regular-tobacco smoking (daily or more than twice a week).
Participant, who was regularly using alcohol, while concurrently using any sort of illicit drug or regularly using tobacco, was characterized as polysubstance use.
The term of ‘SGBV’ referred to any sex worker self-reporting an act of violence from an intimate male partner (husband, boyfriend, or non-paying partner) or paying male clients, and which resulted in, or was likely to result in, physical, sexual harm or suffering to participants, whether occurring in the work place or in their private life.
The term of ‘unmet need for modern contraception’ was defined as not currently intending to get pregnant, but neither using any modern contraception (sterilisation, oral contraceptive pill, intra-uterine device, diaphragm, injection, emergency contraception, or implant), nor consistently using condom with any sexual partners.
The term of ‘inconsistent condom use’ was defined as not always using condoms in the past month, including when drunk or under the influence of drugs with intimate male partners and/or male clients.
The term of ‘any self-reported symptom of STIs’ was included at least one symptom of unusual vaginal discharge, vaginal itching, frequent burning pain on urination, genital ulcers/scores.
The term of ‘safe medical care’ was defined as formally supervised by governmental health department and operated by registered and well-trained medical staff; on the contrary, ‘unsafe medical care’ was defined as seeking treatment at unregistered small clinic or from self-employed, unqualified health workers, or using self-medication, or no any treatment at all.
Data management and analysis
Interviewers were paired and logical errors in the questionnaires were cross-checked on a daily basis. Paper-based data was double-entered using EpiData version 3.1 by trained staff. Identified discrepancies were corrected in line with the original questionnaires.
Analyses were performed using Stata version 13.0 (Stata Corp, College Station, Texas, USA). The ability to correct for complex sample designs in analyzing survey data is an important advantage of Stata. Using clustering samples in this study might reduce the accuracy of estimates (increases the standard error) rather than pure random samples. Therefore, our primary analytic approach was to adjust the potential intra-class correlation within 27 clusters (seeds), the syntax of ‘svyset ‘command was used to describe the sample design, then the’ ‘svy:’ prefix was used before other commands of probit analysis. Survey-adjusted odds ratios are presented for the initial bivariate model and the final multivariate model, respectively.
Descriptive analysis was employed to characterize the participants. Pearson’s Chi-squared tests and Wilcoxon rank sum tests were used to assess associations between independent variables and dependent variables. Dependent variable with p-value less than 0.05 in descriptive analysis were included in the bivariate logistic analysis, and variables at the p < 0.05 significant level in bivariate analysis were selected for inclusion in the multivariable model by using a stepwise forward-fitting approach; all independent variables had been identified the multi-collinearity (variance inflation factor < 10) before entering into multivariable logistic analysis. Independent variables that did markedly alter the model’s fit were removed from the model, and only the variables that had p-values less than 0.05 were retained in the final multivariable model. The Akaike information criterion (AIC) has been used as a measure of goodness-of-fit during the model-selection procedure, the multivariable model with the smallest value of AIC was considered as the final model. Missing responses on selected variables were not included in our analysis.
Ethics approvals and permissions to the study protocol, informed consent forms, information sheets and other requested documents, or any subsequent modifications—were obtained from the ethical committee of the Kunming Public Health Bureau. All interviewers received training in research ethics, including non-judgmental interview skills and confidentiality.
None of the participants were under the age of 15 years old in our study, all participants were clearly informed about the study objectives, the confidential nature of information collected, and their rights of voluntary participation including refusal to answer questions and withdrawal from the study. All participants provided their written informed consent before the interview. For participants who were under the age of 18, given the fact that they were estranged from the parents and living independently in daily life, under this circumstance, adolescents were more knowledgeable about their own situation than their parents, and their priorities and preferences may be at odds with their family and community of origin. In addition, the results of prior focus group discussions indicated that it was neither feasible nor appropriate to obtain parental/guardian consent because there was a risk of breaking their confidentiality, and posing potential barriers hindering their inclusion in this research, a formal written informed consent was additionally obtained from an adult peer selected by the respective participant. Confidentiality was maintained during the recruitment process, questionnaire administration and data storage.
Two existing drop-in centres operated by FSW-led grassroots organizations provided an informal safe space for victims of SGBV to join group or personal activities including medical treatment and peer support. The centres organised referral for clinical care services when indicated.
A total of 378 adolescent FSWs were approached. Of these, 342 women (90%) were eligible and consented to participate and 310 (91%) completed the interview and included in the analysis.
Descriptive statistics of socio-demographic characteristics
The median self-reported age of the study participants was 19 years (inter-quartile range 18–19 years). 54% of the AFSWs had average of 9–12 years of secondary education and 18% had 13–15 years of secondary education. Over half the participants were married or cohabiting (53%; 165/310). Most AFSWs were new rural-to-urban migrants (83%; 257/310). The majority of the participants also reported that they newly entered sex work industry for less than 6 months (62%; 191/310) (Table 1).
Patterns of substance use
The overall prevalence of regular-tobacco smoking was 44% (136/310) among enrolled AFSWs. The illicit drug use was reported by 9% (27/310) of the participants. Not surprisingly, our study revealed a high prevalence of regular-alcohol drinking (83%, 257/310) among AFSWs (Table 1).
The prevalence of concurrent substance use is also identified in this study: a majority of illicit drug-using participants were also drinking alcohol (96%; 26/27) and smoking tobacco regularly (85%; 23/27); whilst a majority of AFSWs who regularly smoke tobacco were also regularly drinking alcohol (95%; 129/136) (Table 1). The 84% (259) of participants were concurrently using polysubstance (Table 2).
Main characteristics of AFSWs who use substance
In comparison with abstainers or occasional alcohol-drinking AFSWs, regularly alcohol-drinking AFSWs were more likely to have middle school education (58% vs. 30%) and to gain higher income from sex work (74% vs. 43%), to be exposed to SGBV (44% vs. 11%) and illicit drug–using partners (23% vs. 2%), to engage in unprotected sex while drunk (35% vs. 13%) and inconsistent condom use with male partners (75% vs. 59%), to report unmet need for modern contraception (39% vs. 17%), prior abortion (48% vs. 23%) and symptom of STIs (71% vs. 42%), to use illicit drug (10% vs. 2%) and to regularly smoke tobacco (50% vs. 2%). Moreover they are less likely to access HIV testing service (42% vs. 64%) in the past year (Table 1).
In comparison with abstainers or occasionally tobacco-smoking AFSWs, participants who regularly smoke tobacco were less likely to enter sex work more than half-year duration (54% vs. 67%); they were more likely to have higher monthly income (79% vs. 62%), to experience sex debut at earlier adolescence (Interquartile Range: 16–17 vs. 17–18); to encounter illicit drug–using partners (17% vs. 2%) and SGBV (49% vs. 29%); to engage in unprotected sex while drunk (43% vs. 22%) and inconsistent condom use with male partners (78% vs. 68%); to report STIs symptoms (82% vs. 53%) and prior abortion (52% vs. 38%); to use unreliable health providers for STIs treatment (45% vs. 27%); to drink alcohol regularly (99% vs. 70%) and use illicit drug (17% vs. 2%) (Table 1).
In comparison with abstainers, illicit drug-using AFSWs were more likely to report higher monthly income (89% vs. 67%); to be exposed to forced sex debut (56% vs. 19%), illicit drug-using partners (56% vs. 16%) and SGBV (70% vs. 35%); to report inconsistent condom use with male partners (89% vs. 71%), prior abortion (63% vs. 23%) and symptom of STIs (85% vs. 42%); and to use unreliable health providers for STIs treatment (73% vs. 31%), (Table 2).
In comparison with abstainers, polysubstance-using AFSWs were more likely to have middle school education (59% vs. 27%) and higher monthly income (74% vs. 45%); to be exposed to illicit drug-using partners (22% vs. 2%) and SGBV (43% vs. 12%); to report inconsistent condom use with male partners (75% vs. 59%), unprotected sex while drunk (35% vs. 14%), unmet need for modern contraception (39% vs. 16%), prior abortion (48% vs. 22%) and STIs symptoms (71% vs. 41%). On the other hand, they are less likely to access HIV testing service (42% vs. 62%) in the past year (Table 2).
Factors associated with regular-alcohol drinking
Table 3 summarized the results of final multivariable logistic regression model of factors associated with regular-alcohol drinking after adjusting for all factors associated in bivariate analysis. AFSWs who had middle and high school education (7-9th grade: adjusted odds ration ‘AOR’ = 5.33; 95%CI = 2.37–12.00, 10-12th grade: AOR = 3.27; 95%CI = 1.01–10.59), had higher monthly income (AOR = 3.26; 95%CI = 1.50–7.10), experienced of SGBV (AOR = 4.29; 95%CI = 1.55–11.85) and prior abortion (AOR = 2.70; 95%CI = 1.17–6.22), and regular-tobacco smoking (AOR = 42.11; 95%CI = 5.54–320.36) were associated with significantly increased odds of regular-alcohol drinking.
Factors associated with regular-tobacco smoking
Four factors were detected to associate with AFSWs’ regular-tobacco smoking in the final multivariate logistic regression models (Table 4). AFSWs had the unprotected sex while drunk had a 1.8-fold odds of regular-tobacco smoking compared to those who did not (95%CI = 1.04–3.15); AFSWs with STIs symptoms had a 2.8-fold odds of regular-tobacco smoking compared to the AFSWs who did not (95%CI = 1.55–5.01); AFSWs who used illicit drug was associated with a greater than 6 times of the odds to regular smoking (95%CI = 2.00–23.36); similarly, AFSWs who regularly drink alcohol had a 40-fold higher odds of regular-tobacco smoking (95%CI = 5.43–299.76).
Factors associated with illicit drug use
In multivariate analysis, AFSWs who had an illicit drug using- intimate partner (AOR =5.77; 95%CI = 2.33–14.29), experienced forced sexual initiation (AOR = 4.41; 95%CI = 1.77–11.06), utilization of unsafe medical providers for STIs treatment or no treatment at all (AOR = 5.98; 95%CI = 2.26–15.85) were associate with increased odds of illicit drug use (Table 5).
Factors associated with polysubstance use
AFSWs who had middle and high school education (7-9th grade: AOR = 6.81; 95%CI = 3.09–15.01, 10-12th grade: AOR = 4.26; 95%CI = 1.39–13.00), had higher monthly income (AOR = 2.94; 95%CI = 1.40–6.14), experienced of SGBV (AOR = 5.74; 95%CI = 2.19–15.05), had unmet need for modern contraception (AOR = 3.47; 95%CI = 1.44–8.40), reported prior abortion (AOR = 2.95; 95%CI = 1.31–6.64) were associated with a significantly increased odds of polysubstance use (Table 6).
The needs for comprehensive sexual and reproductive health services
In this study, we identified comprehensive SRH service needs among AFSWs. The need of free and available HIV/STIs pre-and post-test counselling services was reported by the majority of respondents (69%; 214/309), which was followed by an access to free condom and education of proper condom use (61%; 189/309) (Table 5). Other significant needs including affordable and safe abortion, maternity and gynaecology services (45%; 139/309), STIs diagnosis and treatment services (42%; 129/309), easy access to counselling (42%; 129/309) and available contraception methods services (21%; 65/309) (data not shown in table).
Our findings were brought to light that 65% (193/298) of adolescent women sought STIs treatment from a safe healthcare providers; while other 35% (105/298) were from untrained providers or having a self-medication, or no treatment at all, of whom 87% (91/105) were using polysubstance (Tables 2).
To our knowledge, this is first study to report the high prevalence of concurrent polysubstance use including alcohol, illicit drug and cigarettes, as well as their relations to multiple SRH risks among AFSWs in China. Furthermore, the basic data of the AFSWs’ holistic SRH needs are essential for designing and improving the intervention programme.
Developing specific intervention to mitigate the alcohol and tobacco-related harms
Several studies confirmed the harm arising from alcohol use as an internationally public health challenge for adolescents. For example, alcohol use disorders explained 5% of all mental, neurological, and substance use disorder burden in China . Available data also showed that, heavier alcohol consumption in late adolescence continues into adulthood and is also associated with alcohol problems including alcohol use disorder . The Healthy China Action Plan (2019–2030)  is a new and ambitious initiative to achieve the better health for everyone. This blueprint sets targets for tobacco control, including a reduction in the rate of smoking to 24.5% by 2022 and 20% by 2030; however, there is no specific target towards alcohol consumption control.
Moreover, traditional HIV or SRH intervention targeting FSWs rarely addresses the harm of alcohol, let alone focusing on AFSWs. At a practical level for intervention, understanding AFSWs’ work environment and economic condition has the implications to intervention design. Binge drinking is common in many sex work venues, where alcohol or varieties of alcoholic beverages outlets financially benefit sex workers, alcohol consumption of FSWs and their clients become a significant source of income . Our study clearly demonstrated the high prevalence (83%) of heavier alcohol intake among AFSWs, the rate was much higher than general adolescent population (7.3%) in China . Most AFSWs were new rural-to-urban migrants which face to economic pressures, the higher frequency of situational and environmental alcohol assumption meant the higher income obtained; meanwhile it implies a deeply intertwined link between sex work and alcohol consumption for AFSWs, in turn put them at risk of alcohol use disorder, unwanted or unsafe sex, violence and HIV/STIs.
Tobacco use is another major public health issue among AFSW. Individuals struggling financially face greater incentivizes to smoke as a coping response than those who are financially secure , in this study, given the striking rates of regular smoking among AFSWs, which is much higher than their school-based adolescent counterparts (44% vs. 14.7%) in national data , there is a need for integrating counselling about the risks of alcohol and tobacco prevention for AFSWs, especially pay attention to new rural-to-urban female migrants in young age; other interventions focused on financial security and welfare, job skills training, housing and legal services should be available in public health campaigns targeting marginalized youth and adolescents.
From a perspective of the population-based approach, in China, the effectiveness of current tobacco control policy in general adolescents and youth needs to be strengthened. China has been a signatory country to the WHO Framework Convention on Tobacco Control since 2006, but China is the world’s largest producer with a high-burden of tobacco-use and, one of five focus countries for the Bloomberg Initiative to Reduce Tobacco Use. Cigarettes are cheap in China, and have become more affordable over time; meanwhile alcohol and cigarettes are easy accessed for adolescents, these are important factors influencing the adolescents’ smoking and drink prevalence . Current health policy and plan should advance controlling overall alcohol and tobacco consumption to mitigate the harms from adolescents and young adults, the pricing, restriction of advertisement and purchasing age are most cost-effective strategies, which lie at the legislation, taxation and strict implementation of policies.
The absence of universal comprehensive sexuality and substance prevention education is another important gap needed to be addressed in China . Despite higher average levels of education were found to associate with benefits of adolescent health and wellbeing in countries of low and middle income , whereas our analysis demonstrated that more schooling attained did not protect them from heavier alcohol consumption and polysubstance use in comparison to participants with lower education level (illiterate or primary education), the result was contrary to our hypothesis. This should not be taken as evidence that education is not the protective factor for adolescents’ health and wellbeing, but the finding may reflect the fact that the inadequate or inappropriate education regarding substance prevention and sexuality failed to empower female adolescents with necessary knowledge and skills before them dropping out of school and entering into the workplaces. These findings converge to suggest the importance of integrating substance prevention and SRH promoting into primary and secondary school settings. This approach should be tailored as local context-related, age-related and gender-sensitive, particularly in areas with high prevalence of and health burden related to illicit drug, alcohol and tobacco use, such as Yunnan Province.
Supporting links between harm reduction and SRH care services
The findings of this study confirm that AFSWs with illicit drug use were 5.9 times more likely to use unreliable health providers for STIs treatment than those without illicit drug use; moreover, of the 105 participants sought medical treatment from unsafe providers, or used self-medication, or no treatment at all for their STIs symptoms, the majority (87%; 91/105) of them using polysubstance. For illicit drug use, Chinese current registration system of the public policy sector meant that adolescent incarcerators were all registered as drug users and under the surveillance of police for as long as 3 years after their last positive drug test. Therefore, they could be questioned or tested for drugs by police at any time in this surveillance period . In addition, the criminal records (arrested as a drug user) will brand them for life (drive license and identity card). The criminalization, policies and practices are obvious barriers of applying for a job and social welfare, and can also foster and perpetuate adolescent’ vulnerability to social exclusive and discrimination in healthcare settings. Social taboos against sexually active adolescents, fear of disclosure of illegal behaviours, fear of prejudice from healthcare workers, inconvenient time schedule and locations of health facilities, lack of medical insurance and adequate information, are all likely to deter or discourage AFSWs from seeking the SRH and substance treatment from qualified healthcare service providers .
In this study, the triple jeopardy facing AFSW, these include concurrent substance use, combined SRH risks and less access to qualified healthcare services. This reality highlights the importance of interweaving key programmatic elements of harm reduction with SRH service including HIV/STIs intervention, for example: early warning systems for substance abuse, communication strategies of prevention, guidelines for managing alcohol and other substance abuse -related disorders, as well as training for health workers to eliminate discrimination towards AFSWs.
Risky intimate partners contribute to AFSWs’ substance use and SRH risks
There has been clear and consistent evidence of an association between heavy drink or drinking large amounts per occasion and intimate partner violence . A review found that alcohol use by FSWs and their clients reduced safer sex and social interactions, but this area remains under researched . A line of research showed traumatic events, such as experiencing violent victimization, has a significant impact on adolescents’ poor mental health and female first cigarette use behaviour . Our findings from bivariate logistic regression analysis examined the significant association between risky partners and AFSWs’ substance use, reflecting the gendered issue. Our previous study also showed illicit drug using-AFSWs were more likely to select drug-using intimate partner, potential reasons could be drug supply and/or economic gains; or may be invited or hired to share partners’ drugs [34, 37]; in this situation, AFSWs may lose control of dose, use pattern and use venue, consequently inhibiting their ability to negotiate safe sex, which in turn expose them to higher SRH risks, particularly HIV/STIs . Thus, effective substance use interventions need to address low-control or unequal power relationships between risky intimate partners and AFSWs. Peer support and youth’s rights-based efforts can join forces to draw attention to their unique circumstances and protect them from risky intimate partners.
Limitation and priorities for further research
These findings need to be interpreted in light of certain limitations. Firstly, the cross-sectional nature of this study prevents the attribution of causality, thus we could not assess the temporal sequence. Secondly, given the severe penalties for illicit drug use, fear of disclosure of illicit drug use may have resulted in the cases of illicit drug use and drug-using partners being underreported. In consolidating future directions, there is valuable for research evaluating the effectiveness and efficiency of evidence-based interventions from integrated healthcare settings that meet vulnerable adolescent women’ needs.
SRH and rights are, in turn, fundamental for adolescent women’s wellbeing and full participation in society , and are integral to the core targets of Global Strategy for Women’s, Children’s, and Adolescents’ Health (2016–2030)  and the Healthy China Action Plan (2019–2030) . As a highly marginalized and vulnerable population, AFSWs have an equal chance to survive, thrive and contribute to the transformative change envisioned by social development goals. Achieving the goals will require legal and policy reforms to address structural barriers in a systematic way. A lack of integration of intervention delivery platforms has hindered service utilization and efficacy to deal with AFSWs’ overlapping vulnerabilities. This study emphasises that coordinated efforts are needed to integrate SRH promotion and harm reduction service action across sectors, and not only fragmented measures, our suggestions are not merely based on assumptions, but informed by evidence.
Availability of data and materials
A minimal dataset is available upon request.
Adolescent female sex workers
Akaike information criterion
Adjusted odds ratio
Sexual and gender-based violence
Sexual and reproductive health
Sexually transmitted infections
Department of Economic and Social Affairs; Population Division of United Nations, World population prospects: the 2015 revision. 2015. Available online: https://esa.un.org/unpd/wpp/ (Accessed on 19 Jul 2016).
Galati AJ. Onward to 2030- sexual and reproductive health and rights in the context of the sustainable development goals. Guttmacher Policy Rev. 2015;18(4):77–84.
Every Woman Every Child. The Global Strategy for Women's, Children's and Adolescents' Health (2016–2030): Survive, Thrive, Transform: UN Secretary-Genera. 2015. Available online: http://globalstrategy.everywomaneverychild.org/pdf/EWEC_globalstrategyreport_200915_FINAL_WEB.pdf (Accessed on 9 Nov 2015).
Patton GC, Sawyer SM, Santelli JS, Ross DA, fi RA, Allen NB, Arora M, Viner RM. Our future: a lancet commission on adolescent health and wellbeing. Lancet. 2016;387(10036):2423–78.
Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2019;394(10204):1145–58.
Mokdad AH, Forouzanfar MH, Daoud F, Mokdad AA, Bcheraoui CE, Moradi-Lakeh M, et al. Global burden of diseases, injuries, and risk factors for young people's health during 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2016;387(10036):2383–401.
Starrs AM, Ezeh AC, Barker G, Basu A, Bertrand JT, Blum R, et al. Accelerate progress—sexual and reproductive health and rights for all: report of the Guttmacher– lancet commission. Lancet. 2018;391(10140):2642–92.
Woog V, Singh S, Browne A, Philbin J. Adolescent women’s need for and use of sexual and reproductive health services in developing countries. New York: Guttmacher Institute; 2015.
United Nations Development Programme. Sex work and the law in Asia and the Pacific. 2012. Available online: https://www.undp.org/content/undp/en/home/librarypage/hiv-aids/sex-work-and-the-law-in-asia-and-the-pacific.html (accessed on 10 Apr 2013).
Auerswald, C. L.; Piatt, A. A.; Mirzazadeh, A., Research with Disadvantaged, Vulnerable and/or Marginalized Adolescents-Innocenti Research Briefs, No. 4, Methods: Conducting Research with Adolescents in Low- and Middle-Income Countries. UNICEF Office of Research-Innocenti. 2017. Available online: https://www.unicef-irc.org/adolescentresearch-methods/ (accessed on 2 June 2017).
Hu Y-K, Zheng X-Y, Cheng G. Sexual and reproductive health of Chinese youth is urgently needed to put on the policy agenda. J Int Reprod Health Fam Plan. 2010;29(6):392–6 [in Chinese].
Ditmore, M. H. When sex work and drug use overlap: Considerations for advocacy and practice. 2013. Available online: https://www.nswp.org/resource/when-sex-work-and-drug-use-overlap-considerations-advocacy-and-practice (accessed on 27 Dec 2013).
Engel G. The need for a new medical model: a challenge for biomedicine. Science. 1977;196(4286):129–36.
Edozien L. Beyond biology: the biopsychosocial model and its application in obstetrics and gynaecology. BJOG Int J Obstet Gynaecol. 2015;122(7):900–3.
Baumrind D. The influence of parenting style on adolescent competence and substance use. J Early Adolesc. 1991;11(1):56–95.
China National Narcotics Control Commission (NNCC). 2019 Report on Drug Control in China. Beijing; 2020. Available online: http://www.gov.cn/xinwen/2020-06/25/content_5521774.htm (accessed on 26 June 2020).
Peng Z-H, Cheng Y-J, Reilly KH. Spatial distribution of HIV/AIDS in Yunnan province, People’s Republic of China. Geospatial Health. 2011;5(2):177–82.
Chen F-F, Guo W, Qin Q-Q, Cai C, Cui Y. Spatial-temporal distribution of newly detected HIV/AIDS cases among aged 15 years or older women in China. Chin J Epidemiol. 2018;39(6):739–44.
Hu T, Mao Z, Ong MK, Tong EK, Tao M, Jiang H, et al. China at the crossroads: the economics of tobacco and health. Tob Control. 2006;15(suppl 1):i37–41.
Li L, Chen L, Yang Y. Population estimation, HIV/AIDSknowledge awareness and risk behaviour among female sex workers in Kunming, Yunnan. J Dermatol Venereol. 2009;31(2):1–2 [In Chinese].
Zhang X-D, Kennedy E, Temmerman M, Li Y, Zhang W-H, Luchters S. High rates of abortion and low levels of contraceptive use among adolescent female sex workers in Kunming, China: a cross-sectional analysis. Eur J Contracept Reprod Health Care. 2014;19(5):368–78.
Zhang H, Hsieh E, Wang L, Liao S. HIV/AIDS among female sex Workers in China: epidemiology and recent prevention strategies. Curr HIV/AIDS Rep. 2020;17(2):151–60.
World Health Organization. WHO Survey Questionnaire for Young People. Available online:http://www.who.int/reproductive-health/adolescent/Adolescent_core_instruments.en.html (accessed on 13 June 2011).
Badan Pusat Statistik (BPS)-Statistics Indonesia. The Indonesia DHS Survey 2007: Young Adult Reproductive Health Survey Questionnaire. 2008. Available online:http://dhsprogram.com/pubs/pdf/FR219/FR219.pdf (accessed on 22 June 2010).
Luchters S, Sarna A, Geibel S, Chersich MF, Munyao P, Kaai S, et al. Safer sexual behaviors after 12 months of antiretroviral treatment in Mombasa, Kenya: a prospective cohort. AIDS Patient Care STDs. 2008;22(7):587–94.
Patel V, Chisholm D, Parikh R, Charlson FJ, Degenhardt L, Dua T, et al. Addressing the burden of mental, neurological, and substance use disorders: key messages from disease control priorities, 3rd edition. Lancet. 2016;387(10028):1672–85.
McCambridge J, McAlaney J, Rowe R. Adult consequences of late adolescent alcohol consumption: a systematic review of cohort studies. PLoS Med. 2011;8(2):e1000413 PubMed PMID: 21346802. Pubmed Central PMCID: 3035611.
Health China Promotion Committee. Healthy China Action Plan (2019–2030): The State Coucil of China. 2019. Available online: http://www.gov.cn/xinwen/2019-07/15/content_5409694.htm (accessed on 30 Jul 2019).
Guo L, Deng J, He Y, Deng X, Huang J, Huang G, et al. Alcohol use and alcohol-related problems among adolescents in China: a large-scale cross-sectional study. Medicine. 2016;95(38):e4533.
Friedman AS. Smoking to cope: Addictive behavior as a response to mental distress. J Health Econ. 2020;72(102323). https://doi.org/10.1016/j.jhealeco.2020.102323.
China CDC. 2019 Tobacco use survey report on Chinese students of middle and high School. 2020. Available from: https://china.huanqiu.com/article/3ySTbYMLdaa (accessed 31 May 31, 2020).
Burki T. Sex education in China leaves young vulnerable to infection. Lancet Infect Dis. 2016;16(1):26.
State Council of the People's Republic of China. Regulation on Drug Rehabilitation Beijing: State Coucil. 2011. Available from: http://www.gov.cn/zwgk/2011-06/26/content_1892716.htm (accessed on 09 Mar 2012).
Zhang X-D, Kelly-Hanku A, Chai J-J, Luo J, Temmerman M, Luchters S. Sexual and reproductive health risks amongst female adolescents who use amphetamine-type stimulants and sell sex: a qualitative inquiry in Yunnan, China. Harm Reduct J. 2015;12:34.
Wilson IM, Graham K, Taft A. Alcohol interventions, alcohol policy and intimate partner violence: a systematic review. BMC Public Health. 2014;14:881.
Luchters S, Richter ML, Bosire W, et al. The contribution of emotional partners to sexual risk taking and violence among female sex workers in Mombasa, Kenya: A cohort study. PLoS ONE. 2013;8(8):e68855.
Li Q, Li X, Stanton B. Alcohol use among female sex workers and male clients: an integrative review. Alcohol Alcohol. 2011;45(2):188–99.
Zuccala E, Horton R. Addressing the unfinished agenda on sexual and reproductive health and rights in the SDG era. Lancet. 2018;391(10140):2581–3.
The authors would like to thank all the participants and stakeholders who generously gave their trust, time and information. The authors also thank Mr. Dabo Mamoudou for his editing help on the reversion of this article. The authors are deeply grateful for the valuable comments provided by the editors and peer reviewers of Journal of Substance Abuse Treatment Prevention and Policy.
RX was supported by Chinese National Foundation of Social Sciences (13BZX031, PI: RX); XZ was supported by Open Research Scheme of Yunnan Provincial First Public Hospital (2017ZDKFKT002, PI: XZ). The content and publish decision are solely the responsibility of the authors and do not necessarily represent the official views of financial funders.
Ethics approval and consent to participate
The study was conducted following four principles of the Declaration of the 1978 Belmont Report: non-maleficence (do no harm), respect for persons, beneficence (maximize benefits), and justice; in addition, the 2017 UNICEF Innocenti Brief ‘Inclusion with Protection when Conducting Research with Adolescents’ was served as an important ethical guidelines for implementation of field work. Ethics approvals and permissions were obtained from the ethical committee of the Kunming Public Health Bureau (protocol number: 2012/001) and all participants gave written informed consent.
Consent for publication
The authors have no financial or personal relationships that might bias this work and no conflicts of interest in the manuscript.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Zhang, XD., Zhang, J., Xie, RS. et al. Sexual and reproductive health correlates of polysubstance use among female adolescents who sell sex in the southwest of China. Subst Abuse Treat Prev Policy 15, 59 (2020). https://doi.org/10.1186/s13011-020-00302-5
- Female sex worker
- Substance use
- Sexual and reproductive health, China