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Table 1 Baseline characteristics of the participants (n = 676)

From: Liver stiffness and associated risk factors among people with a history of injecting drugs: a prospective cohort study

Sex n (%)

 Females

185 (27)

 Males

491 (73)

Age groups, years n (%)

 18—29

81 (12)

 30—39

200 (26)

 40 – 49

200 (26)

 50—59

160 (24)

 60 + 

35 (5)

Age, mean (SD)

43 (11)

BMI kg/m2, mean (SD)

25 (4.8)

Housing situation past 30 days1 n (%)

 Stable

587 (87)

 Unstable

89 (13)

Highest completed education n (%)

 Not finished basic education2

34 (5)

 Finished basic education2

310 (46)

 High school3

266 (39)

  < 3 years of higher education

51 (8)

  > 3 years of higher education

15 (2)

Current OAT medication n (%)

 Methadone

220 (33)

 Buprenorphine-based

322 (48)

 Naltrexone

1 (0.2)

 None

133 (20)

Regular substance use4 n (%)

 Alcohol

163 (26)

 Tobacco

587 (93)

 Cannabis

324 (51)

 Stimulants

187 (30)

 Opioids

99 (16)

 Benzodiazepines

236 (37)

iSUSI5, mean (SD)

0.36 (0.23)

Injected past 12 months6 n (%)

344 (55)

Hepatitis B antigen positive n (%)

 < 5 (0.7)

HIV positive n (%)

 < 5 (0.7)

Hepatitis C status n (%)

 Antibody negative

56 (8)

 Antibody positive, RNA negative

251(37)

 RNA positive

310(46)

 Missing information7

59 (9)

Blood tests mean (SD)

 Alanine transaminase U/L

53 (67)

 Aspartate transaminase U/L

49 (49)

 Thrombocytes 109/L

246 (80)

 Estimated glomerular filtration rate ml/min/1,73m2

107(26)

Liver disease risk factors and markers n (%)

 HbA1c elevated8

14 (2)

 Low HDL9

173 (26)

 Low thrombocytes10

62 (9)

 Obesity11 ≥ 30 kg/m2

104 (15)

 Liver stiffness12 ≥ 10 kPa

83 (12)

  1. Missing values are not included in the percentages
  2. 1Living in an owned or rented home or being incarcerated was defined as a stable housing situation, while living in a homeless shelter, with family or friends, or on the street was defined as an unstable housing situation
  3. 2In Norway, the first ten school years are mandatory for all pupils
  4. 3Grades 11–13
  5. 4Substance used more regularly than once a week for the past 12 months
  6. 5The illegal substance use severity index is a continuous variable ranging from 0–1, were (1) indicates the effect of maximum substance use and (0) indicates the effect of no substance use
  7. 6Intravenous injection of drugs at least once during the past 12 months
  8. 7No information on hepatitis C status registered
  9. 8Defined as HbA1c > 48 mmol/mol, which is diagnostic of diabetes [35]
  10. 9Values below 1.3 mmol/L for women and 1.0 mmol/L for men are defined as low [36, 37]
  11. 10Thrombocyte count of < 150 × 109/L is defined as low and is associated with an increased risk of portal hypertension [27]
  12. 11BMI ≥ 30 kg/m2 increases the risk of severe liver disease outcome [38]
  13. 12Liver stiffness ≥ 10 kPa indicates an increased risk of compensated advanced chronic liver disease [27]