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Table 10 Critical appraisal of quantitative studies reporting fatal and non-fatal overdose

From: The impact of relaxing restrictions on take-home doses during the COVID-19 pandemic on program effectiveness and client experiences in opioid agonist treatment: a mixed methods systematic review

No

Study

MMAT Section 3a for quantitative non-randomized studies

1

2

3

4

5

Are the participants representative of the target population?

Are measurements appropriate regarding both the outcome and intervention (or exposure)?

Are there complete outcome data?

Are the confounders accounted for in the design and analysis?b

During the study period, is the intervention administered (or exposure occurred) as intended?b

S2

Aldabergenov et al., 2022 [70]

Yes

Yes

Yes

No

No

S3

Amram et al., 2021 [71]

No

Yes

Yes

Yes

Yes

S6

Corace et al., 2022 [74]

No

No

Yes

No

Yes

S8

Ezie et al., 2022 [76]

Yes

Can't tell

Yes

No

Can't tell

S13

Gomes et al., 2022 [81]

Yes

Yes

Yes

Yes

Yes

S17

Joseph et al., 2021 [85]

Can't tell

No

No

No

No

S26

Nguyen et al., 2021 [94]

No

Yes

Yes

No

No

# meeting quality criteria

3/7

4/7

6/7

2/7

3/7

  1. aThe MMAT (Mixed Methods Appraisal Tool) Qualitative Checklist is designed specifically for mixed methods systematic reviews (Hong et al., 2018). It consists of five sections specific to various study designs, each with five quality criteria. All quantitative studies included in this review, including quantitative components of mixed-methods studies, were appraised under Sect. 3: Quantitative non-randomized studies
  2. bThis review included studies in which the intervention of interest (relaxed restrictions on take-home doses) formed part of a broader intervention (e.g., pandemic-related changes to OAT treatment). To increase the relevancy of the quality assessments, we interpreted questions 4 and 5 relevant to the research question posed in this review