Table 1 Ovid Medline Search Strategy

1

methadone.mp

2

exp Methadone/

3

exp Buprenorphine/

4

exp Buprenorphine, Naloxone Drug Combination/

5

buprenorphine.mp

6

buprenorphine-suboxone.mp

7

exp Methadyl Acetate/

8

Methadyl Acetate.mp

9

"methadone maintenance".mp

10

"methadone maintenance therapy".mp

11

"methadone maintenance treatment".mp

12

"methadone substitution".mp

13

"buprenorphine maintenance therapy".mp

14

exp Opiate Substitution Treatment/

15

"opiate substitution treatment".mp

16

"opioid substitution therapy".mp

17

exp Narcotic Antagonists/

18

"opioid agonist therapy".mp

19

"opioid agonist treatment".mp

20

"opiate substitution".mp

21

"opiate substitute".mp

22

"opioid substitute".mp

23

"opioid replacement".mp

24

"medications for opioid use disorder".mp

25

1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24

26

rural.mp

27

Rural Health/

28

Rural Health Services/

29

Rural Population/

30

remote.mp

31

regional.mp

32

Health Services, Indigenous/

33

aborigin*.mp

34

exp Indigenous Peoples/

35

indigenous.mp

36

exp Indigenous Canadians/

37

Inuits/

38

inuit.mp

39

exp Indians, North American/

40

metis.mp

41

"first nation".mp

42

"first nations".mp

43

"native people".mp

44

"native peoples".mp

45

amerindian.mp

46

exp American Natives/

47

"native american".mp

48

"native americans".mp

49

exp Alaskan Natives/

50

"alaska* native".mp

51

American Native Continental Ancestry Group/

52

26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 48 or 49 or 50 or 51

53

25 and 52

54

exp Canada/

55

(british columbia or alberta or saskatchewan or manitoba or ontario or quebec or new brunswick or nova scotia or prince Edward island or newfoundland or labrador or nunavut or nwt or northwest territories or yukon or nunavik or Inuvialuit).mp. [mp = title, abstract, original title, name of substance word, subject heading word, floating sub-heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms]

56

canad*.mp

57

54 or 55 or 56

58

53 and 57

59

north america/ or exp united states/ or exp Canada/

60

53 and 59

61

55 or 56 or 59

62

53 and 61

63

limit 62 to english language

64

limit 63 to yr = "2001—2022"