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Table 4 Effect modification by gender on association between overdose risk and having reported using a kit – Adjusted odds ratios and 99% confidence intervals for odds of having reported using a kit vs not having reported using a kit, stratified by gender

From: Factors associated with take-home naloxone kit usage in British Columbia: an analysis of administrative data

Variable

Unstratified (N = 189,178)

Gender: Male (N = 99,738)

Gender: Female (N = 86,633)

Gender: OtherA (N = 2,807)

AOR* (99% CI)

p-value

AOR (99% CI)

p-value

AOR (99% CI)

p-value

AOR (99% CI)

p-value

Risk of Overdose

 Not at Risk

1.00

-

1.00

-

1.00

-

1.00

-

 At Risk

6.82 (6.57 – 7.09)

 < 0.001

5.37 (5.08 – 5.67)

 < 0.001

8.35 (7.90 – 8.82)

 < 0.001

3.68 (2.82 – 4.79)

 < 0.001

Year

 2017

1.00

-

1.00

-

1.00

-

1.00

-

 2018

1.59 (1.53 – 1.66)

 < 0.001

1.59 (1.50 – 1.68)

 < 0.001

1.63 (1.52 – 1.74)

 < 0.001

1.25 (0.79 – 1.97)

0.206

 2019

1.85 (1.77 – 1.93)

 < 0.001

1.85 (1.75 – 1.96)

 < 0.001

1.87 (1.75 – 2.00)

 < 0.001

1.17 (0.72 – 1.90)

0.396

 2020

2.76 (2.65 – 2.88)

 < 0.001

2.77 (2.63 – 2.93)

 < 0.001

2.83 (2.65 – 3.02)

 < 0.001

2.20 (1.41 – 3.43)

 < 0.001

Health Region

 Fraser

1.00

-

1.00

-

1.00

-

1.00

-

 Interior

1.35 (1.30 – 1.40)

 < 0.001

1.46 (1.39 – 1.53)

 < 0.001

1.27 (1.20 – 1.34)

 < 0.001

0.50 (0.35 – 0.72)

 < 0.001

 Island

1.35 (1.30 – 1.40)

 < 0.001

1.49 (1.42 – 1.56)

 < 0.001

1.20 (1.14 – 1.27)

 < 0.001

1.11 (0.81 – 1.53)

0.388

 Northern

0.70 (0.67 – 0.74)

 < 0.001

0.74 (0.69 – 0.79)

 < 0.001

0.66 (0.61 – 0.71)

 < 0.001

1.06 (0.61 – 1.84)

0.792

 Vancouver Coastal

0.99 (0.95 – 1.04)

0.664

1.07 (1.01 – 1.14)

0.001

0.91 (0.85 – 0.97)

 < 0.001

0.76 (0.53 – 1.10)

0.059

Age Group

 Under 19

1.00

-

1.00

-

1.00

-

1.00

-

 19—30

1.94 (1.81 – 2.07)

 < 0.001

1.84 (1.67 – 2.03)

 < 0.001

2.05 (1.86 – 2.25)

 < 0.001

1.87 (1.21 – 2.89)

 < 0.001

 31—60

2.19 (2.05 – 2.34)

 < 0.001

2.14 (1.95 – 2.35)

 < 0.001

2.24 (2.04 – 2.46)

 < 0.001

1.83 (1.20 – 2.80)

 < 0.001

 Over 60

1.35 (1.22 – 1.49)

 < 0.001

1.36 (1.18 – 1.56)

 < 0.001

1.29 (1.10 – 1.52)

 < 0.001

1.35 (0.66 – 2.77)

0.276

  1. Abbreviations: AOR adjusted odds ratio
  2. * Odds ratio between each group and the reference group for each variable, after adjusting for all other variables: overdose risk, year, health region, age group