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Table 3 Associations between serum methadone concentrations and the study variables in 83 participants by using adjusteda linear mixed model

From: Subjective symptoms and serum methadone concentrations: what should guide dose adjustments in methadone maintenance treatment? A naturalistic cohort study from Norway

  β-coefficient 95% CI b p-value
Total SOWSc Score − 4.3 − 5.6, − 2.9 < 0.001
Anxiety − 0.5 − 0.8, − 0.2 0.004
Bone- and muscle ache − 0.5 − 0.9, − 0.2 0.003
Restlessness − 0.5 − 9.7, − 0.9 0.017
Shaking − 0.3 − 0.6, − 0 0.046
Nausea (as adverse effect) 0.3 − 0.1, 0.6 0.057
Heroin use − 0.2 − 0.4, − 0 0.015
Alcohol use − 0.4 − 0.7, − 0.1 0.011
Cannabis use 0.5 0, 10.4 0.049
  1. a Adjusted for age, gender and absolute time difference between blood sampling and record of the symptoms
  2. b Confidence interval
  3. c Subjective opioid withdrawal symptoms