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Table 3 Comparison of Provider-Perceived Efficacy of Buprenorphine vs. Methadone. Detailed Table Summary: When comparing physician perspectives about buprenorphine and methadone to treat OUD, respondents believed that buprenorphine is slightly more effective than methadone in decreasing the risks of opioid-overdose death (paired t (67) = 0.265, p = 0.035)

From: A mixed-method comparison of physician-reported beliefs about and barriers to treatment with medications for opioid use disorder

Perceptions Buprenorphine Methadone t df Mean of the Difference Cohen’s d 95% Confidence Interval p
n Mean (SD) n Mean (SD) Lower Upper
MOUD decreases risk of death from opioid overdose 68 4.294 (0.978) 68 4.029 (0.946) 2.147 67 0.265 0.275 0.019 0.511 0.035*
MOUD decreases cravings for opioids 66 4.349 (0.969) 66 4.227 (0.873) 1.070 65 0.121 0.132 −0.105 0.347 0.288
MOUD decreases rates of relapse 65 4.154 (1.004) 65 4.092 (0.931) 0.541 64 0.062 0.064 −0.166 0.289 0.590
MOUD works well in patients with co-occurring mental health disorders 63 4.016 (1.100) 63 4.032 (0.950) −0.142 62 −0.016 0.016 −0.240 0.208 0.888
MOUD should be supplemented by mental health counseling 71 4.521 (0.954) 71 4.549 (0.842) −0.363 70 −0.028 0.031 −0.183 0.127 0.718
MOUD should be supplemented by participation in peer support groups 69 4.333 (0.950) 69 4.391 (0.878) −0.754 68 −0.058 0.063 −0.212 0.096 0.454
MOUD efficacy is improved by adding mental health counseling 69 4.551 (0.796) 69 4.391 (0.973) 1.469 68 0.159 0.180 −0.057 0.376 0.146
  1. Notes: MOUD medication for opioid use disorder. Questions asked about the MOUDs buprenorphine and methadone were compared in these results using paired samples t-tests (alpha = 0.05, two-tailed level). * indicates significance at the α = .05 level