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Table 1 Comparison of Provider-Perceived Efficacy of Buprenorphine vs. Extended-Release Naltrexone. Detailed Table Summary: Respondents believed that buprenorphine decreases opioid cravings more than extended-release naltrexone (paired t [37]=4.474, p < 0.001). Respondents believed that buprenorphine, to a greater degree than extended-release naltrexone, decreases the risk of fatal opioid-overdose (paired t [38]=3.413, p = 0.001), decreases return to opioid misuse (paired t [39]=2.078, p = 0.043), and works well in patients with co-occurring mental health disorders (paired t [39]=2.461, p = 0.017).

From: A mixed-method comparison of physician-reported beliefs about and barriers to treatment with medications for opioid use disorder

Perceptions

Buprenorphine

Naltrexone

t

df

Mean of the Difference

Cohen’s d

95% Confidence Interval

p

n

Mean (SD)

n

Mean (SD)

Lower

Upper

MOUD decreases risk of death from opioid overdose

52

4.327 (1.024)

52

3.769 (0.921)

3.413

51

0.558

0.755

0.230

0.885

0.001*

MOUD decreases cravings for opioids

53

4.491 (0.869)

53

3.566 (1.118)

4.474

52

0.925

0.924

0.510

1.339

< 0.001*

MOUD decreases rates of relapse

50

4.200 (1.030)

50

3.840 (0.792)

2.078

49

0.360

0.392

0.012

0.708

0.043*

MOUD works well in patients with co-occurring mental health disorders

50

4.220 (0.996)

50

3.780 (0.954)

2.461

49

0.440

0.451

0.081

0.799

0.017*

MOUD should be supplemented by mental health counseling

56

4.571 (0.806)

56

4.393 (0.846)

1.563

55

0.179

0.215

−0.050

0.408

0.124

MOUD should be supplemented by participation in peer support groups

57

4.298 (0.999)

57

4.193 (1.043)

0.973

56

0.105

0.103

−0.111

0.322

0.335

MOUD efficacy is improved by adding mental health counseling

56

4.518 (0.853)

56

4.429 (0.828)

0.962

55

0.089

0.106

−0.0979

0.2756

0.001*

  1. Notes: MOUD medication for opioid use disorder. Questions asked about the MOUDs buprenorphine and extended-release naltrexone were compared in these results using paired samples t-tests (alpha = 0.05, two-tailed level). * indicates significance at the α = .05 level