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Table 3 Results for multi-level analyses of the associations with percentages of drug consumption in Antipyretic; Analgesic; Anti-inflammatory drugs

From: Consumption of pharmaceutical drugs in exception region of separation for drug prescribing and dispensing program in South Korea

Variables

Antipyretic; Analgesic; Anti-inflammatory drugs

Model 1

Model 2

Model 3

Model 4

β

SE

t

df

P-Value

β

SE

t

df

P-Value

β

SE

t

df

P-Value

β

SE

t

df

P-Value

Intercept

9.51

0.08

120.05

246

<.0001

12.68

0.99

12.80

246

<.0001

9.23

0.27

34.53

241

<.0001

12.26

1.02

12.03

241

<.0001

Pharmacy characteristics

                    

Sex of pharmacist

                    

 Male

     

0.64

0.13

5.00

243

<.0001

     

0.52

0.13

4.03

243

<.0001

 Female

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Age of pharmacist (years)

                    

 ≤45

     

−0.65

0.18

−3.62

722

0.0003

     

−0.66

0.18

−3.65

722

0.0003

 46–55

     

−0.82

0.18

−4.48

722

<.0001

     

−0.82

0.18

−4.45

722

<.0001

 56–65

     

−0.62

0.19

−3.26

722

0.0012

     

−0.59

0.19

−3.07

722

0.0022

 ≥66

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Length of operation

                    

 ≤12 months

     

−1.06

0.20

−5.35

454

<.0001

     

−1.08

0.20

−5.47

454

<.0001

 13–24 months

     

−0.80

0.20

−3.97

454

<.0001

     

−0.81

0.20

−4.01

454

<.0001

 ≥25 months

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Separation of drug prescribing and dispensing

                    

 Exception

     

3.41

0.82

4.14

93

<.0001

     

3.19

0.82

3.88

93

0.0002

 Application

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Period of exclusion for reformed program

                    

 ≤18 months

     

−1.05

0.98

−1.07

88

0.2860

     

−0.93

0.98

−0.95

88

0.3455

 ≥19 months

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Total drug purchase (10 million KRW)

     

−0.02

0.00

−25.37

16,000

<.0001

     

−0.02

0.00

−25.93

16,000

<.0001

Regional characteristics

                    

Region

                    

 Metropolitan

          

−0.53

0.16

−3.22

241

0.0015

−0.56

0.16

−3.57

241

0.0004

 Non-metropolitan

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Total number of clinics in regions with pharmacies

                    

 ≤60

          

0.21

0.21

1.03

241

0.3027

0.12

0.20

0.61

241

0.5431

 ≥61

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Total number of pharmacy in regions with pharmacies

                    

 ≤45

          

−0.18

0.19

−0.92

241

0.3597

−0.17

0.18

−0.92

241

0.3574

 ≥46

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Average of individual income in regions with pharmacies

                    

 ≤38 million KRW

          

0.47

0.17

2.73

241

0.0067

0.43

0.16

2.63

241

0.0091

 ≥39 million KRW

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Ref

-

  

-

Proportion of national basic livelihood security beneficiaries in regions with pharmacies

          

0.07

0.06

1.21

241

0.2271

0.14

0.05

2.72

241

0.0070

Random parta

Variance

SE

Z

P-Value

Variance

SE

Z

P-Value

Variance

SE

Z

P-Value

Variance

SD

Z

P-Value

Variance of the intercept at the regional level

0.39

0.12

3.26

0.0005

0.35

0.11

3.26

0.0006

0.27

0.10

2.55

0.0054

0.20

0.09

2.29

0.0111

Variance of the intercept at the pharmacy level

65.48

0.73

90.21

<.0001

61.92

0.69

90.23

<.0001

65.44

0.73

90.24

<.0001

61.85

0.69

90.28

<.0001

ICC

0.0059

   

0.0055

   

0.0040

   

0.0032

   
  1. Note. The results of multilevel linear regression analysis using mixed model to examine associations between program designation (i.e., exception region or application region) and percentages of drug consumption (antipyretic, analgesic, anti-inflammatory drugs, and psychotropic drugs, adrenal cortical hormones, and antibiotics) in hierarchical data which was consisted of pharmacy and regional levels. Significant level P < 0.05. If these values were lower than 0.05, it indicated that there were statistically significant associations between independent variable and drug consumption
  2. Model 1 = empty model, Model 2 = only adjusted for pharmacy-level variables, Model 3 = only adjusted regional-level variables, Model 4 = fully adjusted
  3. KRW Republic of Korea Won, ICC Intra-class Correlation Coefficient, the results were rounded to the second digit after the decimal point, df degrees of freedom
  4. aIf p-value were lower than 0.05, it indicated that each level variable had statistically significant association with the outcome variables. The ICC was defined that the ratio of the between cluster variance to the total variance. It was interpreted as the correlation among observations within the same cluster