Table 1 A table with a synthesis of above-presented data referring to zinc misbalances in conditions of opioid administration is presented below
biological fluid or structure where zinc concentration was determined | zinc concentration evolution compared to controls and mechanisms or details (where available) | ||
|---|---|---|---|
serum or plasma | decreased | Sadlik J. et al., 2000 (humans – in case of heroin users; tendency to normalize upon detoxification treatment, but not reaching levels in control group) [44] | |
Elnimr T. et al., 1999 (humans – correlated with the abuse period) [45] | |||
Ruiz Martinez M. et al., 1999 (humans – accompanied by increased copper) [46] | |||
Iyengar V. et al., 1994 (humans – due to increased renal elimination) [69] | |||
increased | Floriańczyk B., 2000 (mice, morphine) [77] | ||
red blood cells | decreased | Ruiz Martinez M. et al., 1999 (humans) [46] | |
cerebrospinal fluid | decreased | Potkin S.G. et al., 1982 (humans) [47] | |
other tissues | brain | decreased | Floriańczyk B., 2000 (mice, morphine) [77] |
Gulya K. et al., 1991 (rats) (parietal cortex, hippocampus and striatum) – induced by the δ- agonist (D-Pen2, D-Pen5)enkephalin, antagonized by naloxon [11] | |||
liver | increased | Hidalgo J. et al., 1991 (rats, morphine) [75] | |
decreased | Floriańczyk B., 2000 (mice, morphine) [77] | ||
lungs, kidney | decreased | Floriańczyk B., 2000 (mice, morphine) [77] | |
heart, spleen, muscle | increased | Floriańczyk B., 2000 (mice, morphine) [77] | |