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Table 1 A table with a synthesis of above-presented data referring to zinc misbalances in conditions of opioid administration is presented below

From: Zinc involvement in opioid addiction and analgesia – should zinc supplementation be recommended for opioid-treated persons?

biological fluid or structure where zinc concentration was determined zinc concentration evolution compared to controls and mechanisms or details (where available)
serum or plasma decreased Sadlik J. et al., 2000 (humans – in case of heroin users; tendency to normalize upon detoxification treatment, but not reaching levels in control group) [44]
Elnimr T. et al., 1999 (humans – correlated with the abuse period) [45]
Ruiz Martinez M. et al., 1999 (humans – accompanied by increased copper) [46]
Iyengar V. et al., 1994 (humans – due to increased renal elimination) [69]
increased Floriańczyk B., 2000 (mice, morphine) [77]
red blood cells decreased Ruiz Martinez M. et al., 1999 (humans) [46]
cerebrospinal fluid decreased Potkin S.G. et al., 1982 (humans) [47]
other tissues brain decreased Floriańczyk B., 2000 (mice, morphine) [77]
Gulya K. et al., 1991 (rats) (parietal cortex, hippocampus and striatum) – induced by the δ- agonist (D-Pen2, D-Pen5)enkephalin, antagonized by naloxon [11]
liver increased Hidalgo J. et al., 1991 (rats, morphine) [75]
decreased Floriańczyk B., 2000 (mice, morphine) [77]
lungs, kidney decreased Floriańczyk B., 2000 (mice, morphine) [77]
heart, spleen, muscle increased Floriańczyk B., 2000 (mice, morphine) [77]