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Table 1 Co-medications among patients used within the last 24 h before testing at T1 and T2

From: Memory function in opioid-dependent patients treated with methadone or buprenorphine along with benzodiazepine: longitudinal change in comparison to healthy individuals

  Methadone (n= 13) Buprenorphine or Buprenorphine/Naloxone (n= 15)
  Proportion of patients Dose, range Proportion of patients Dose, range
Antidepressants (any), T1/T2 54%/46%   40%/53%  
   Citalopram T1 8% 40 mg - -
   Citalopram T2 - - 13% 10 mg
   Escitalopram T1 8% 5 mg - -
   Escitalopram T2 8% 10 mg - -
   Doxepine T1 - - 13% 75 – 100 mg
   Doxepine T2 8% 50 mg 20% 25 – 100 mg
   Fluoxetine T1 15% 20 – 30 mg - -
   Fluoxetine T2 8% 40 mg - -
   Milnacipran T1 - - - -
   Milnacipran T2 - - 7% 50 mg
   Mirtazapine T1 25% 15 – 30 mg - -
   Mirtazapine T2 25% 30 mg 7% 30 mg
   Paroxetine T1 8% 50 mg 7% 50 mg
   Paroxetine T2 - - 13% 40 mg
   Sertraline T1 - - 7% 50 mg
   Sertraline T2 - - 7% 50 mg
   Trimipramine T1 - - - -
   Trimipramine T2 8% 150 mg - -
   Venlafaxine T1 - - 13% 75 mg
   Venlafaxine T2 - - 7% 75 mg
Anxiolytics, sedatives and hypnotics: Benzodiazepines (any), T1/T2 87%/100%   93%/100%  
   Alpratzolam T1 - - 13% 1 – 2 mg
   Alpratzolam T2 - - 13% 1 – 2 mg
   Clonazepam T1 - - 13% 2 – 5 mg
   Clonazepam T2 - - - -
   Diazepam T1 46% 10 – 55 mg 47% 10 – 40 mg
   Diazepam T2 38% 15 – 30 mg 67% 5 – 30 mg
   Oxazepam T1 31% 60 – 120 mg 33% 30 – 90 mg
   Oxazepam T2 46% 15 – 60 mg 20% 55 – 60 mg
   MidazolamT1a - - - -
   MidazolamT2a - - 7% 30 mg
   Temazepam T1a 31% 20 mg 13% 20 mg
   Temazepam T2a 15% 20 – 40 mg 13% 20 – 40 mg
Non-benzodiazepine hypnotics (any), T1/T2 15%/8%   20%/7%  
   Zolpidem T1a - - - -
   Zolpidem T2a 8% 10 mg 7% 10 mg
   Zopiclone T1a 15% 7.5 mg 20% 7.5 – 15 mg
   Zopiclone T2a 8% 7.5 mg 7% 7.5 mg
Neuroleptics (any), T1/T2 b 20%/8%   7%/7%  
   Levomepromazine T1 - - - -
   Levomepromazine T2 8% 50 mg - -
   Quetiapine T1 20% 50 – 300 mg 7% 300 mg
   Quetiapine T2 - - 7% 150 mg
   Rispiderone T1 - - - -
   Rispiderone T2 8% - - -
Substance abuse withdrawal symptom or (non-opioid) pain relievers (any), T1/T2 42%/25%   40%/13%  
   Disulfiram T2 - - - -
   Disulfiram T2 8% 600 mg - -
   Hydroxyzine T1 25% 25 – 200 mg 27% 75 – 200 mg
   Hydroxyzine T2 8% 50 mg 7% 100 mg
   Ibuprofen T1 8% 600 mg 7% 400 mg
   Ibuprofen T2 - - 7% 600 mg
   Lofexidine T1 8% 0,2 mg 20% 0.2 – 0.6 mg
   Lofexidine T2 - - - -
   Metoclopramide T1 8% 10 mg - -
   Metoclopramide T2 - - - -
   Naproxen T1 8% 500 mg - -
   Naproxen T2 - - - -
   Propranol T1 8% 20 mg - -
   Propranol T2 - - - -
   Valproate T1 8% 1000 mg 20% 500 – 1000 mg
   Valproate T2 - - 7% 100 mg
  1. a Used as a hypnotic on the night before testing.
  2. b Used for anxiolysis.