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Table 4 Results

From: The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification

  Buprenorphine
(total = 42)
Dihydrocodeine
(total = 48)
Relative Risk
(95% CI)
Unpaired t-test P value
By end of detox
   Final urine sample 32/42 31/48 1.18 (0.90, 1.54) N/A 0.43
   Per protocol negative urine 24/32 17/31 1.37 (0.94, 1.99) N/A 0.10
   ITT negative urine 24/42 17/48 1.61 (1.02, 2.56) N/A 0.04
   Leaving early 10/42 15/48 0.76 (0.38, 1.51) N/A 0.43
   Overdose 0 0 N/A   
   Inappropriate use of allocated drug 3/29 1/25 2.59 (0.29,23.32) N/A 0.39
   A&E attendance 0 0   N/A  
   Hospital admittance 0 0   N/A  
   Prison doctor visits (mean) 1.0 (0.5) n = 28 1.0 (0.6) n = 23 N/A t(49) = 0.00 1.00
At 1 months post detoxification
   Dead 0/33 0/33   N/A  
   Abstinent (ITT) 16/42 17/48 1.08 (0.63, 1.85) N/A 0.79
   How known?      
Urine test 4/10 2/5 1.00 (0.27, 3.72) N/A  
Self report 12/21 15/25 0.95 (0.58, 1.55) N/A 1.00
   A&E attendance 0/33 0/33   N/A 0.84
   Hospital attendance 0/33 0/33   N/A  
Prison doctor visits (mean) 0.4 (0.9) n = 25 0.6 (1.0) n = 28 N/A t(51) = 0.76 0.45
Drug worker visits
(mean)
0.2 (0.4) n = 3 2 n = 1   N/A  
At 3 months post detoxification
   Dead 0/27 0/23   N/A  
   Abstinent (ITT) 13/42 12/48 1.24 (0.64, 2.41 N/A 0.53
   How known?      
Urine test 2/8 1/4 1.00 (0.13, 8.00) N/A 1.00
Self report 11/18 11/18 1.00 (0.59, 1.68) N/A 1.00
   A&E attendance 1/27 1/23 0.85 (0.06,12.87) N/A 0.91
   Hospital attendance 2/27 1/23 1.70 (0.16,17.60) N/A 0.65
   Prison doctor visits (mean) 0.8 (1.7) n = 17 1.5 (1.9) n = 17 N/A t(32) = 0.76 0.27
   Drug worker visits (mean) 0 No data   N/A  
At 6 months post detoxification
   Dead 0/14 0/12    
   Abstinent 5/42 5/48 1.14 (0.36, 3.68) N/A 0.82
   How known?      
Urine test 1/3 1/4 1.33(0.13,13.74) N/A 0.81
Self report 4/11 4/8 0.73 (0.26, 2.07) N/A 0.55
   A&E attendance 2/14 1/12 1.71(0.18,16.65) N/A 0.64
   Hospital attendance 3/14 2/12 1.29 (0.26, 6.46) N/A 0.76
   Prison doctor visits (mean) 2.0 (2.2) n = 4 2.2 (1.5) n = 4 N/A   
   Drug worker visits (mean) No data N/A  
  1. *ITT assumption = everybody not returning for final urine test had positive urine
  2. * Statistical tests were z (approximation) tests