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Table 4 Results

From: The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification

 

Buprenorphine

(total = 42)

Dihydrocodeine

(total = 48)

Relative Risk

(95% CI)

Unpaired t-test

P value

By end of detox

   Final urine sample

32/42

31/48

1.18 (0.90, 1.54)

N/A

0.43

   Per protocol negative urine

24/32

17/31

1.37 (0.94, 1.99)

N/A

0.10

   ITT negative urine

24/42

17/48

1.61 (1.02, 2.56)

N/A

0.04

   Leaving early

10/42

15/48

0.76 (0.38, 1.51)

N/A

0.43

   Overdose

0

0

N/A

  

   Inappropriate use of allocated drug

3/29

1/25

2.59 (0.29,23.32)

N/A

0.39

   A&E attendance

0

0

 

N/A

 

   Hospital admittance

0

0

 

N/A

 

   Prison doctor visits (mean)

1.0 (0.5) n = 28

1.0 (0.6) n = 23

N/A

t(49) = 0.00

1.00

At 1 months post detoxification

   Dead

0/33

0/33

 

N/A

 

   Abstinent (ITT)

16/42

17/48

1.08 (0.63, 1.85)

N/A

0.79

   How known?

     

Urine test

4/10

2/5

1.00 (0.27, 3.72)

N/A

 

Self report

12/21

15/25

0.95 (0.58, 1.55)

N/A

1.00

   A&E attendance

0/33

0/33

 

N/A

0.84

   Hospital attendance

0/33

0/33

 

N/A

 

Prison doctor visits (mean)

0.4 (0.9) n = 25

0.6 (1.0) n = 28

N/A

t(51) = 0.76

0.45

Drug worker visits

(mean)

0.2 (0.4) n = 3

2 n = 1

 

N/A

 

At 3 months post detoxification

   Dead

0/27

0/23

 

N/A

 

   Abstinent (ITT)

13/42

12/48

1.24 (0.64, 2.41

N/A

0.53

   How known?

     

Urine test

2/8

1/4

1.00 (0.13, 8.00)

N/A

1.00

Self report

11/18

11/18

1.00 (0.59, 1.68)

N/A

1.00

   A&E attendance

1/27

1/23

0.85 (0.06,12.87)

N/A

0.91

   Hospital attendance

2/27

1/23

1.70 (0.16,17.60)

N/A

0.65

   Prison doctor visits (mean)

0.8 (1.7) n = 17

1.5 (1.9) n = 17

N/A

t(32) = 0.76

0.27

   Drug worker visits (mean)

0

No data

 

N/A

 

At 6 months post detoxification

   Dead

0/14

0/12

   

   Abstinent

5/42

5/48

1.14 (0.36, 3.68)

N/A

0.82

   How known?

     

Urine test

1/3

1/4

1.33(0.13,13.74)

N/A

0.81

Self report

4/11

4/8

0.73 (0.26, 2.07)

N/A

0.55

   A&E attendance

2/14

1/12

1.71(0.18,16.65)

N/A

0.64

   Hospital attendance

3/14

2/12

1.29 (0.26, 6.46)

N/A

0.76

   Prison doctor visits (mean)

2.0 (2.2) n = 4

2.2 (1.5) n = 4

N/A

  

   Drug worker visits (mean)

No data

N/A

 
  1. *ITT assumption = everybody not returning for final urine test had positive urine
  2. * Statistical tests were z (approximation) tests
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