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Table 1 Bivariate relationships between substance use disorders (SUD) and interferon (IFN) completion and response rates among veterans with available hepatitis C (HCV) genotypes

From: Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disorders

 

SUD- Group

SUD+ Group

   
 

N

%

N

%

OR

95% CI

p

Known vs. Unknown Genotype

       

   Not available

42

12.0%

52

11.2%

1.08

0.70–1.67

0.718

   Available

308

88.0%

413

88.8%

   

Genotypes 2 & 3

       

Completed ≥ 22 Weeks of IFN

       

   No

29

26.9%

56

32.0%

0.78

0.46 – 1.33

0.359

   Yes

79

73.1%

119

68.0%

   

End of Treatment Response (ETR)

       

   Not available

8

7.4%

9

5.1%

1.38

0.51 – 3.74

0.528

   Available

71

65.7%

110

62.9%

   

No Response

14

13.0%

15

8.6%

1.56

0.70 – 3.46

0.276

Response

57

52.8%

95

54.3%

   

Sustained Viral Response (SVR)

       

   Not available

4

3.7%

8

4.6%

0.79

0.23 – 2.73

0.705

   Available

61

56.5%

96

54.9%

   

No Response

15

13.9%

24

13.7%

0.98

0.47 – 2.06

0.954

Response

46

42.6%

72

41.1%

   

Genotypes 1 & 4

       

Completed ≥ 46 Weeks of IFN

       

   No

121

60.5%

143

60.1%

1.02

0.69 – 1.49

0.929

   Yes

79

39.5%

95

39.9%

   

End of Treatment Response (ETR)

       

   Not available

9

8.3%

19

10.9%

0.51

0.22 – 1.21

0.124

   Available

70

64.8%

76

43.4%

   

No Response

21

19.4%

17

9.7%

1.49

0.71 – 3.13

0.294

Response

49

45.4%

59

33.7%

   

Sustained Viral Response (SVR)

       

   Not available

3

2.8%

4

2.3%

1.01

0.22 – 4.69

0.991

   Available

55

50.9%

74

42.3%

   

No Response

23

21.3%

21

12.0%

1.81

0.87 – 3.79

0.111

Response

32

29.6%

53

30.3%

   
  1. CI = Confidence interval, ETR = End of treatment response, IFN = Interferon, OR = Odds ratio, SUD = Substance use disorder, SVR = Sustained viral response. ORs reflect the SUD+ Group compared with the SUD- Group. The SUD+ Group includes veterans with a history of substance use disorder. The SUD- Group includes veterans with no history of substance use disorder. Completion rates are based on all patients with available genotypes. Response rates are based on all patients with known HCV genotypes who initiated IFN therapy. Patients were considered non-responders if they failed to clear the virus or if they were lost to follow-up (e.g., unavailable ETR or SVR).