Table 2 Treatment studies of bipolar disorder with co-occurring SUDs.
From: The prevalence and significance of substance use disorders in bipolar type I and II disorder
Treatment Study | Design | Treatment | Number of patients | SUD | Results |
|---|---|---|---|---|---|
Geller et al. [28] | double-blind placebo-controlled | Lithium | 12 bipolar I; 5 bipolar II | Alcohol or drug dependence | Improvement in affective and SUD symptoms |
Salloum et al. [46] | double-blind placebo-controlled | Valproate (as adjunct to lithium) | 59 bipolar I | Alcohol dependence | Improvement in SUD but not affective symptoms |
Brown et al. [27] | Open-label | Aripiprazole | 18 bipolar I; 1 bipolar II; 1 schizoaffective disorder, bipolar type | Alcohol or drug abuse or dependence | Improvement in affective and SUD symptoms |
Brown et al. [45] | Open-label | Lamotrigine | 22 bipolar I; 7 bipolar II; 1 bipolar NOS | Cocaine dependence | Improvement in affective and SUD symptoms |
Brown et al. [26] | Open-label | Quetiapine | 14 bipolar I; 3 bipolar II | Cocaine dependence | Improvement in affective symptoms but not SUD symptoms |
Brown et al. [44] | Open-label | Naltrexone | 34 bipolar (type?) | alcohol dependence | Improvement in affective and SUD symptoms |
Drake et al. [47] | Open-label | Integrated dual disorder treatment | 51 bipolar (type unspecified) | Alcohol or drug abuse or dependence | Improvement in SUD but not affective symptoms |
Schmitz et al. [33] | Open-label | Cognitive therapy as an adjunct to medication | 46 bipolar (type unspecified) | Alcohol or drug abuse or dependence | Improvement in affective symptoms but not SUD symptoms |
Weiss et al. [34] | Open-label | Integrated group therapy | 50 bipolar I; 10 bipolar II; 2 bipolar NOS | Alcohol or drug dependence | Improvement in SUD but not affective symptoms |