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Table 2 Treatment studies of bipolar disorder with co-occurring SUDs.

From: The prevalence and significance of substance use disorders in bipolar type I and II disorder

Treatment Study Design Treatment Number of patients SUD Results
Geller et al. [28] double-blind placebo-controlled Lithium 12 bipolar I; 5 bipolar II Alcohol or drug dependence Improvement in affective and SUD symptoms
Salloum et al. [46] double-blind placebo-controlled Valproate (as adjunct to lithium) 59 bipolar I Alcohol dependence Improvement in SUD but not affective symptoms
Brown et al. [27] Open-label Aripiprazole 18 bipolar I; 1 bipolar II; 1 schizoaffective disorder, bipolar type Alcohol or drug abuse or dependence Improvement in affective and SUD symptoms
Brown et al. [45] Open-label Lamotrigine 22 bipolar I; 7 bipolar II; 1 bipolar NOS Cocaine dependence Improvement in affective and SUD symptoms
Brown et al. [26] Open-label Quetiapine 14 bipolar I; 3 bipolar II Cocaine dependence Improvement in affective symptoms but not SUD symptoms
Brown et al. [44] Open-label Naltrexone 34 bipolar (type?) alcohol dependence Improvement in affective and SUD symptoms
Drake et al. [47] Open-label Integrated dual disorder treatment 51 bipolar (type unspecified) Alcohol or drug abuse or dependence Improvement in SUD but not affective symptoms
Schmitz et al. [33] Open-label Cognitive therapy as an adjunct to medication 46 bipolar (type unspecified) Alcohol or drug abuse or dependence Improvement in affective symptoms but not SUD symptoms
Weiss et al. [34] Open-label Integrated group therapy 50 bipolar I; 10 bipolar II; 2 bipolar NOS Alcohol or drug dependence Improvement in SUD but not affective symptoms