From: The prevalence and significance of substance use disorders in bipolar type I and II disorder
Epidemiological Study | Number of subjects | Lifetime prevalence of co-occurring SUDs in bipolar I (or combined total if type not specified) | Lifetime prevalence of co-occurring SUDs in bipolar II |
---|---|---|---|
NESARC [2] | General Population; 43,093 subjects | 58% for alcohol use disorders; 38% for drug use disorders | Â |
National Institutes of Mental Health Epidemiologic Catchment Area Program [5] | General Population; 20,291 subjects | 61% for any SUD | 48% for any SUD |
Cassidy et al. [6] | 392 bipolar I patients | 48.5% for alcohol abuse; 24.2% for cocaine abuse; 4.6% for opioid abuse; 36% for cannabis abuse. | Â |
McElroy et al. [7] | 239 bipolar I; 49 bipolar II | 36% for alcohol abuse; 10% for cocaine abuse; 8% for opioid abuse; 40% for cannabis abuse. | 22% for alcohol abuse; 4% for cocaine abuse; 0% for opioid abuse; 10% for cannabis abuse. |
Chengappa et al. [35] | 71 bipolar I; 18 bipolar II | 57.8% for alcohol abuse; 11.3% for cocaine abuse; 5.6% for opioid abuse; 19.7% for cannabis abuse. | 38.9% for alcohol abuse; 5.6% for cocaine abuse; 0% for opioid abuse; 5.6% for cannabis abuse. |
The University of Cincinnati First-Episode Mania Study [14, 15] | 144 bipolar I | 42% for alcohol abuse; 46% for cannabis abuse | Â |
The McLean-Harvard First-Episode Mania Study [9] | 112 bipolar I | 33% for any SUD during the index affective episode | Â |
Veterans Affairs (VA) Cooperative Study #450 [10] | 328 bipolar I and II patients (analyzed together) | 61.9% for alcohol abuse; 19.5% for cocaine abuse; 8.5% for opioid abuse; 22.6% for cannabis abuse | Â |