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Table 1 Epidemiology studies examining the prevalence of co-occurring SUDs in bipolar disorder.

From: The prevalence and significance of substance use disorders in bipolar type I and II disorder

Epidemiological Study Number of subjects Lifetime prevalence of co-occurring SUDs in bipolar I (or combined total if type not specified) Lifetime prevalence of co-occurring SUDs in bipolar II
NESARC [2] General Population; 43,093 subjects 58% for alcohol use disorders; 38% for drug use disorders  
National Institutes of Mental Health Epidemiologic Catchment Area Program [5] General Population; 20,291 subjects 61% for any SUD 48% for any SUD
Cassidy et al. [6] 392 bipolar I patients 48.5% for alcohol abuse; 24.2% for cocaine abuse; 4.6% for opioid abuse; 36% for cannabis abuse.  
McElroy et al. [7] 239 bipolar I; 49 bipolar II 36% for alcohol abuse; 10% for cocaine abuse; 8% for opioid abuse; 40% for cannabis abuse. 22% for alcohol abuse; 4% for cocaine abuse; 0% for opioid abuse; 10% for cannabis abuse.
Chengappa et al. [35] 71 bipolar I; 18 bipolar II 57.8% for alcohol abuse; 11.3% for cocaine abuse; 5.6% for opioid abuse; 19.7% for cannabis abuse. 38.9% for alcohol abuse; 5.6% for cocaine abuse; 0% for opioid abuse; 5.6% for cannabis abuse.
The University of Cincinnati First-Episode Mania Study [14, 15] 144 bipolar I 42% for alcohol abuse; 46% for cannabis abuse  
The McLean-Harvard First-Episode Mania Study [9] 112 bipolar I 33% for any SUD during the index affective episode  
Veterans Affairs (VA) Cooperative Study #450 [10] 328 bipolar I and II patients (analyzed together) 61.9% for alcohol abuse; 19.5% for cocaine abuse; 8.5% for opioid abuse; 22.6% for cannabis abuse