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Table 1 Epidemiology studies examining the prevalence of co-occurring SUDs in bipolar disorder.

From: The prevalence and significance of substance use disorders in bipolar type I and II disorder

Epidemiological Study

Number of subjects

Lifetime prevalence of co-occurring SUDs in bipolar I (or combined total if type not specified)

Lifetime prevalence of co-occurring SUDs in bipolar II

NESARC [2]

General Population; 43,093 subjects

58% for alcohol use disorders; 38% for drug use disorders

 

National Institutes of Mental Health Epidemiologic Catchment Area Program [5]

General Population; 20,291 subjects

61% for any SUD

48% for any SUD

Cassidy et al. [6]

392 bipolar I patients

48.5% for alcohol abuse; 24.2% for cocaine abuse; 4.6% for opioid abuse; 36% for cannabis abuse.

 

McElroy et al. [7]

239 bipolar I; 49 bipolar II

36% for alcohol abuse; 10% for cocaine abuse; 8% for opioid abuse; 40% for cannabis abuse.

22% for alcohol abuse; 4% for cocaine abuse; 0% for opioid abuse; 10% for cannabis abuse.

Chengappa et al. [35]

71 bipolar I; 18 bipolar II

57.8% for alcohol abuse; 11.3% for cocaine abuse; 5.6% for opioid abuse; 19.7% for cannabis abuse.

38.9% for alcohol abuse; 5.6% for cocaine abuse; 0% for opioid abuse; 5.6% for cannabis abuse.

The University of Cincinnati First-Episode Mania Study [14, 15]

144 bipolar I

42% for alcohol abuse; 46% for cannabis abuse

 

The McLean-Harvard First-Episode Mania Study [9]

112 bipolar I

33% for any SUD during the index affective episode

 

Veterans Affairs (VA) Cooperative Study #450 [10]

328 bipolar I and II patients (analyzed together)

61.9% for alcohol abuse; 19.5% for cocaine abuse; 8.5% for opioid abuse; 22.6% for cannabis abuse

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