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Table 3 Summary of data about toxicology of thujone

From: Absinthism: a fictitious 19th century syndrome with present impact

Toxicity data Reference
oral LD50 in rats 192 mg/kg bw [66]
oral LD50 in rats 500 mg/kg bw [107]
iv LD50 in rabbits 0.031 mg/kg bw [107]
NOEL for convulsions in rats 12.5 mg/kg bw (males) [108]
NOEL for convulsions in rats 5 mg/kg bw (females), 10 mg/kg bw (males) [66]
NOEL for convulsions in rats 5 mg/kg bw [66]
TDI (based on NOEL with safety factor of 500) 10 μg/kg bw/d [66]
Metabolism 2-,4-, and 7-hydroxylation [75,76]
Mechanism of toxicity GABA Type A modulation (α-thujone neurotoxicity, convulsant effects) [72,74,76]
Mechanism of toxicity Porphyrogenicity (determined in cultures of chick embryo liver cells) [46]
Behavioral effects 5-HT3 receptor modulation, but no conclusive evidence for psychotropic actions of thujone [77]