From: Consideration of vaping products as an alternative to adult smoking: a narrative review
Year | Design | Main Findings | Reference |
---|---|---|---|
2014 | Aerosol Chemistry | Reduced levels of HPHCs in aerosol from e-cigarette compared to cigarette smoke | [5] |
2016 | Aerosol Chemistry | Reduced levels of HPHCs in aerosol from e-cigarette compared to cigarette smoke | [6] |
2020 | Aerosol Chemistry | Reduced levels of HPHCs in aerosol from e-cigarette compared to cigarette smoke | [7] |
2021 | Aerosol Chemistry | Reduced levels of HPHCs in aerosol from e-cigarette compared to cigarette smoke | |
In vitro toxicology | No significant or low cytotoxicity of e-cigarette aerosol on human bronchial epithelial BEAS-2B cell line | [9] | |
2018 | Aerosol Chemistry | Low levels of aromatic amines, volatile organic compounds, polycycli aromatic hydrocarbon benzo[a]pyrene in e-liquid and aerosol | [10] |
2020 | Aerosol Chemistry | Emission levels for most HPHCs were not detectable in 34 commercially available e-cigarettes. Carbonyls including formaldehyde were detected but variable across devices | [11] |
2014 | In vitro toxicology | No cytotoxicity following exposure to e-cigarette aqueous extracts in human lung epithelial carcinma cells A549. No mutagenic effects in Ames test. No mutagenic effects in micronuclease assay using chinese hamster ovary cells CHO-K1 | [12] |
2020 | In vitro toxicology | No mutagenic effect in Ames test and no genotoxicity in in vitro micronuclease assay following exposure to e-liquids and aerosols. Reduced cytotoxicity of e-cigarette aerosol compared to tobacco smoke | [13] |
2016 | In vitro toxicology | Reduced cytotoxicity in human lung epithelial cells following exposure to e-cigarette aerosol compared to tobacco smoke | [14] |
2017 | In vitro toxicology | Compared several e-cigarettes for cytotoxicity and detected both cytotoxic and non-cytotoxic effects | [15] |
2016 | Cellular and Molecular Changes | No impact of exposure to e-cigarette aerosol on endothelial cell migration compared to cigarette smoke | [16] |
2017 | Cellular and Molecular Changes | No oxidative stress in human bronchial epithelial cells exposed to e-cigarette aersol extracts | [17] |
2016 | Cellular and Molecular Changes | No activation of oxidative stress pathways in human coronary artery endothelial cells in response to e-cigarette aerosol compared to cigarette smoke | [18] |
2019 | Cellular and Molecular Changes | No tissue damage to buccal and small airway cultures, and no impact on cilia beat in small airway cultures following exposure to e-cigarette aerosol. Increased expression of inflammatory genes in buccal cells exposed to e-cigarette aerosols | [19] |
2019 | Cellular and Molecular Changes | Reduced levels of oxidative stress from exposure to e-cigarette aerosol compared to tobacco smoke on human bronchial epithelial cells. Increased expression of inflammatory mediators | [20] |
2019 | Cellular and Molecular Changes | No effect of e-cigarette aerosol on airway epithelial morphology or barrier viability. No difference in immune activation between air exposure and e-cigarettee aerosol exposure | [21] |
2021 | Cellular and Molecular Changes | Biological impact of exposure to e-cigarette reduced in comparison to cigarette smoke including histology, cytotoxicity, cellular function, and gene expression | [22] |
2017 | Cellular and Molecular Changes | Reduced impact of exposure to e-cigarettes on gene expression compared to cigarette smoke | [23] |
2020 | Cellular and Molecular Changes | Similar effect of e-cigarette aerosol and cigarette smoke on barrier integrity of airway epithelial cells. No imact on cilia beat frequency in response to exposure to e-cigarette aerosol | [24] |
2016 | Cellular and Molecular Changes | Differential changes in gene expression in response to exposure to e-cigarette aerosol compared to cigarette smoke. Alterations in glycerophospholipid biosynthesis noted in response to e-cigarette aerosol exposure | [25] |
2017 | Cellular and Molecular Changes | Reduced cellular and gene expression effects in human bronchial epithelial cells following exposure to e-cigarette aerosol compared to cigarette smoke | [26] |
2020 | Cellular and Molecular Changes | Increased salivary inflammatory mediator levels in e-cigarette users compared to non-users | [27] |
2017 | Cellular and Molecular Changes | Reduced bronchial epithelial function in response to exposure to both cigarette smoke and e-cigarette aerosols | [28] |
2020 | Cellular and Molecular Changes | Impaired in vivo (rats) endothelial function in response to exposure to e-cigarette aerosol | [29] |
2016 | Cellular and Molecular Changes | Reduced toxic effects of acute e-cigarette aerosol exposure in C57Bl/6Â J mice compared to cigarette smoke | [30] |
2021 | Cellular and Molecular Changes | Increased levels of fibronectin as a measure of tissue injury in B6C3F1 following exposure to e-cigarette aerosol compared to cigarette smoke | [31] |
2020 | Cellular and Molecular Changes | Exposure to e-cigarette aerosol did not change ceramide profiles or related enzymes in ApoE-/- mice | [32] |
2020 | Cellular and Molecular Changes | Long term (6Â month) exposure to e-cigarette aerosol did not compromise bone integrity in ApoE-/- mice | [33] |
2021 | Cellular and Molecular Changes | Reduction effect of exposure to e-cigarette aerosol on lung function and gene expression in ApoE-/- mice compared to cigarette smoke | [34] |
2020 | Cellular and Molecular Changes | Reduced biological response to exposure to e-cigarette aerosol in ApoE-/- mice compared to cigarette smoke | [35] |
2020 | Cellular and Molecular Changes | Similar effect of e-cigarette aerosol and cigarette smoke on oxidative stress and inflammation related to fibrosis | [36] |
2020 | Cellular and Molecular Changes | Comparable changes in gene expression in Balb/C mice following exposure to e-cigarette aerosol or cigarette smoke | [37] |
2021 | Cellular and Molecular Changes | Activation of nicotine-related gene expression in brains of mice exposed to e-cigarette aerosol | [38] |
2015 | Biomarkers of Exposure | Reduced levels of carbon monoxide, nicotine, and acrolein in urine from individuals after switching to e-cigarettes from combustible cigarettes | [39] |
2017 | Biomarkers of Exposure | Reduced levels of biomarkers of exposure in urine samples from individuals after switching to e-cigarettes from combustible cigarettes | [40] |
2018 | Biomarkers of Exposure | Nicotine-related in saliva were comparable between e-cigarette users and cigarette users. Urine levels of nicotine were not detectable in e-cigarette users | [41] |
2021 | Biomarkers of Exposure | No metal detected in the hair samples of e-cigarette users | [42] |
2021 | Biomarkers of Exposure | Significant reduction in levels of biomarkers of exposure in cigarette users who switched to e-cigarettes. Also reduced in dual users | [43] |
2017 | Biomarkers of Exposure | Reduced blood and urine levels of toxicants in individuals that switch from combustible cigarettes to e-cigarettes | [44] |
2021 | Biomarkers of Exposure | Reduced urine levels of NNAL in individuals who switched from combustible cigarettes to e-cigarettes. Also reduced in dual users | [45] |